Results 51 to 60 of about 2,107 (154)

Tunnelling Nanotube‐Mediated Lysosome Sharing Promotes Osteocyte Survival via Transcellular Autophagy

open access: yesCell Proliferation, EarlyView.
This study provides the first definitive identification of tunnelling nanotubes (TNTs) between cultured osteocytes and shows TNT‐mediated lysosome transfer from healthy to stressed cells, restoring autophagic flux and preventing apoptosis. This discovery of transcellular autophagy reveals a new survival mechanism in osteocytes, offering potential ...
Jinbiao Qiang   +16 more
wiley   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

open access: yesThe FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti   +11 more
wiley   +1 more source

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

open access: yesThe FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal   +4 more
wiley   +1 more source

Genome assembly of Elcysma westwoodi provides insights into host‐plant cyanogenic glucoside detoxification and chemical defence gene evolution

open access: yesInsect Molecular Biology, EarlyView.
A chromosome‐level genome of Elcysma westwoodi was assembled. The genome encodes 272 detoxification‐related genes. A single‐copy bCAS was retained for cyanide detoxification. CYP405A and CYP332A were recruited into cyanogenic defence evolution. UGT33A retained a conserved GT‐B fold and catalytic domains.
Minyoung Choi, Murtaza Khan, Juil Kim
wiley   +1 more source

Religious Participation After Covid‐19: Evidence From US Catholic Dioceses and Smartphone Data

open access: yesJournal for the Scientific Study of Religion, EarlyView.
ABSTRACT How do religious rules and regulations affect behavior? We examine this question using changes in Catholic regulations during the Covid‐19 pandemic combined with mobility data from 15 million smartphone users from 2019 to 2022. We first document overall trends: Total religious attendance declined sharply in March 2020 and thereafter recovered ...
Angela Cools   +2 more
wiley   +1 more source

Taking a position through documentary : a political sociology of documentary movies shot down town Saint-Denis and in la Joliette in Marseille (2000-2010)

open access: yes, 2017
This thesis analyzes the process of politicization and de-politicization of documentary films that focus on stigmatized urban areas. It is based on 42 films made between 2000 and 2010 in the neighborhoods of Centre-ville Basilique in Saint-Denis and La Joliette in Marseille.
openaire   +1 more source

Enforcing intellectual property rights in metaverse gaming platforms: The next steps for the EU's metaverse agenda

open access: yesThe Journal of World Intellectual Property, EarlyView.
Abstract This article delineates a comprehensive framework for the achievement of effective metaverse governance that reflects the EU's current metaverse agenda and promotes respect for intellectual property rights. To do so, this article follows a two‐strand methodology. It engages in a doctrinal legal analysis and a policy‐oriented assessment.
Zoi Krokida, Ioanna Lapatoura
wiley   +1 more source

Seeing the Speaker's Face Enhances Second Language Shadowing: Neural and Behavioral Evidence

open access: yesLanguage Learning, EarlyView.
Abstract This functional magnetic resonance imaging (fMRI) study investigated how facial cues influence second language (L2) shadowing among 42 Japanese learners of English. Participants completed four conditions that varied by task type (listening vs. shadowing) and visual input (face vs. mosaic).
Hyeonjeong Jeong   +7 more
wiley   +1 more source

Genre and Conversation

open access: yesNoûs, EarlyView.
ABSTRACT Conversations can belong to different types, or genres. We consider four dimensions of variation as case studies: Some conversations are about sharing information, others about making decisions; some are about making firm commitments, others about brainstorming options; some are about sticking to the facts, others involve make‐believe; some ...
Elmar Unnsteinsson, Daniel W. Harris
wiley   +1 more source

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