Results 61 to 70 of about 2,137 (177)

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

open access: yesBritish Journal of Pharmacology, EarlyView.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness   +21 more
wiley   +1 more source

CANRIG: Cross‐Attention Neural Face Rigging with Variable Local Control

open access: yesComputer Graphics Forum, EarlyView.
Abstract Facial animation is one of the most labor‐intensive aspects of animation and VFX, as traditional rigging consumes weeks of expert time and forces animators to spend countless hours manipulating hundreds of controls to achieve varied expressions.
Arad Mohammadi   +6 more
wiley   +1 more source

The Story(line) So Far: A Survey on Storyline Visualization

open access: yesComputer Graphics Forum, EarlyView.
Abstract Storyline visualizations model narratives as temporal networks, using x‐monotone lines to represent entities and their interactions over time. This technique offers an intuitive way to reveal structural patterns over time, such as character co‐occurrence and narrative flow.
S. Di Bartolomeo   +4 more
wiley   +1 more source

Advances in 4D Representation: Geometry, Motion, and Interaction

open access: yesComputer Graphics Forum, EarlyView.
We survey 4D representation through three key pillars — geometry, motion, and interaction — offering a selective, representation‐centric perspective to guide researchers in choosing and customizing the right 4D representation for their tasks. Abstract We present a survey on 4D generation and reconstruction, a fast‐evolving subfield of computer graphics
M. Zhao   +7 more
wiley   +1 more source

Cannabis consumption and problematic internet use: analysis of a free-text response collected through a self-reported online questionnaire. [PDF]

open access: yesBMC Psychol
St-Onge J   +10 more
europepmc   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

open access: yesThe FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti   +11 more
wiley   +1 more source

Prevalence and Determinants of Nomophobia Among Healthcare Workers in Nepal: A Cross-Sectional Study. [PDF]

open access: yesCureus
Banjade P   +7 more
europepmc   +1 more source

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

open access: yesThe FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal   +4 more
wiley   +1 more source

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