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Salidroside: An Overview of Its Promising Potential and Diverse Applications [PDF]

Pharmaceuticals
Salidroside, a phenolic compound isolated from various Rhodiola plants, is the principal active constituent of Traditional Chinese Medicine known for its adaptogenic properties.
Keke Liang, Shuhe Ma, Kai Luo, Renjie Wang, Chenrong Xiao, Xianxie Zhang, Yue Gao, Maoxing Li   +7 more
doaj   +5 more sources

Salidroside inhibits melanin synthesis and melanoma growth via mTOR and PI3K/Akt pathways [PDF]

Frontiers in Oncology
BackgroundMelanomas are caused by the malignant transformation of melanocytes. Numerous studies have demonstrated that the tyrosol components of salidroside inhibit tyrosinase activity.
Qi Ouyang, Qi Ouyang, Shengye Tian, Shengye Tian, Hengyu Zhou, Hengyu Zhou, Ying Mao, Xiang Li, Feng Yan, Feng Yan, Ailong Liu, Ailong Liu, Xiang Hu, Changqiao You, Changqiao You, Jun He   +15 more
doaj   +3 more sources

Mesenchymal stem cells enchanced by salidroside to inhibit ferroptosis and improve premature ovarian insufficiency via Keap1/Nrf2/GPX4 signaling [PDF]

Redox Report
Background Regenerative medicine researches have shown that mesenchymal stem cells (MSCs) may be an effective treatment method for premature ovarian insufficiency (POI).
Lixuan Chen, Yingnan Wu, Tiying Lv, Rui Tuo, Yang Xiao   +4 more
doaj   +3 more sources

Salidroside as a Novel Protective Agent to Improve Red Blood Cell Cryopreservation. [PDF]

PLoS ONE, 2016
Glycerol and trehalose have been widely examined as protective agents in the cryopreservation of red blood cells (RBCs). However, the effectiveness of these reagents alone on cell viability is moderate.
Noha A S Alotaibi, Nigel K H Slater, Hassan Rahmoune   +2 more
doaj   +9 more sources

Salidroside and exercise performance in healthy active young adults – an exploratory, randomized, double-blind, placebo-controlled study [PDF]

Journal of the International Society of Sports Nutrition
Background Rhodiola rosea extract is purported to improve physical performance and support resilience to stress. Salidroside is considered to be one of the main constituents responsible for the ergogenic actions of R. rosea. However, R.
Neil A. Schwarz, Matthew T. Stratton, Ryan J. Colquhoun, Alexia M. Manganti, Margaux Sherbourne, Florian Mourey, Caitlyn C. White, Heather Day, Micaela C. Dusseault, Geoffrey M. Hudson, Christopher R. Vickery, Holly C. Schachner, Philip G. Kasprzyk, Jing-Ke Weng   +13 more
doaj   +3 more sources

Salidroside inhibited the proliferation of gastric cancer cells through up-regulating tumor suppressor miR-1343-3p and down-regulating MAP3K6/MMP24 signal molecules

Cancer Biology & Therapy
Salidroside inhibited the proliferation of cancer cell. Nevertheless, the mechanism has not been completely clarified. The purpose of the study is to explore the mechanisms of salidroside against gastric cancer. To analyze the changes of microRNA (miRNA)
Xiaoping Wang, Zhendong Zhang, Xiaolan Cao   +2 more
doaj   +2 more sources

Salidroside inhibits the invasion and migration of colorectal cancer cells by regulating MMP-12 and WNT signaling pathway. [PDF]

Am J Cancer Res
Colorectal cancer (CRC) is a prevalent and highly lethal malignancy, with current therapeutic efficacy limited by the tumor's high invasiveness and metastatic potential. Matrix metalloproteinases (MMPs) and the WNT (Wingless/Integrated) signaling pathway
Hong Y, Li Y, Liu X, Deng J, He Y, Zhao B.   +5 more
europepmc   +2 more sources

Salidroside Improves Oocyte Competence of Reproductively Old Mice by Enhancing Mitophagy. [PDF]

Aging Cell
The decline of oocyte quality with advanced maternal age has a detrimental effect on female fertility. However, there is limited knowledge of therapeutic options and their mechanisms to improve oocyte quality in reproductively older women. In this study,
Gu J, Hua R, Wu H, Guo C, Hai Z, Xiao Y, Yeung WSB, Liu K, Babayev E, Wang T.   +9 more
europepmc   +2 more sources

Structure-based virtual screening aids the identification of glycosyltransferases in the biosynthesis of salidroside. [PDF]

Plant Biotechnol J
Summary Glycosylation plays an important role in the structural diversification of plant natural products. The identification of efficient glycosyltransferases is also a crucial step for the biosynthesis of valuable glycoside products.
Yao Y, Chen F, Wu C, Chang X, Cheng W, Wang Q, Deng Z, Liu T, Lu L.   +8 more
europepmc   +2 more sources

Salidroside protects against myocardial infarction via activating MIF-mediated mitochondrial quality control [PDF]

Chinese Medicine
Background Salidroside is a potential therapeutic agent for myocardial infarction (MI), exerting therapeutic effects on macrophage migration inhibitory factor (MIF)-regulated mitochondrial quality control.
Baiyang You, Jie Zhang, Chuyan Yang, Yaoshan Dun, Dake Qi, Yuqiong Long, Jing Cheng, Yuan Lin, Nanjiang Zhou, Tanghao Zeng, Jie Dong, Suixin Liu   +11 more
doaj   +2 more sources