Results 211 to 220 of about 7,877 (239)

Pharmacokinetics, Tissue Distribution, and Excretion of Salidroside in Rats

Planta Medica, 2013
The present study investigated the pharmacokinetics, excretion, and tissue distribution of salidroside, a main active constituent in the roots of Rhodiola species. The plasma concentration declined rapidly following the intravenous dosing at 7.5, 15, and 30 mg/kg with a short half-life time of about 1 h.
Zhang, Ying, Li, Liqun, Lin, Li, Liu, Jianxun (R17789), Zhang, Zaohua, Xu, Dongjin, Xiang, Feijun   +6 more
openaire   +3 more sources

Salidroside attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis

Journal of Asian natural products research
Salidroside is a traditional Chinese medicine with multiple pharmacological activities such as anti-inflammatory and antioxidant properties, while acute kidney injury (AKI) is a common sepsis-induced acute inflammatory response.
Lingling Zhen, Mingtong Hou, Sheng-Bao Wang   +2 more
semanticscholar   +1 more source

[Microbial synthesis of salidroside].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2019
Salidroside, as one of the main active ingredients of Rhodiala plant, has the effects of anti-hypoxia, anti-radiation, anti-fatigue, anti-tumor, hypoglycemia and improving immunity. With the increasing demand for salidroside and the decreasing of plant resources, microbial production of salidroside has attracted much attention due to its advantages of ...
Feiyan, Xue, Mingfeng, Yang, Lanqing, Ma
openaire   +1 more source

Anti-fatigue effects of salidroside in mice

Journal of Medical Colleges of PLA, 2008
Abstract Objective To study the anti-fatigue effects of salidroside in mice. Methods Totally 120 normal male Kunming mice were randomized into 5 groups (4 salidroside intervention groups and the control group) based on body weight. The control group was given distilled water and the 4 intervention groups were given various doses of salidroside ...
Ma Li, Cai Donglian, Li Huaixing, Tong Bende, Song Lihua, Wang Ying   +5 more
openaire   +1 more source

Salidroside modulates repolarization through stimulating Kv2.1 in rats

European Journal of Pharmacology
Voltage-gated potassium (Kv) channel growth is strongly associated with the development of arrhythmia. Salidroside (Sal), an active component from Rhodiola crenulata, has been shown to exert protective effects against heart disease. The present study was conducted to investigate the effects of Sal on Kv2.1 channel, and to explore the ionic mechanism of
Yating Zhang, Rui Li, Hong Jiang, Ya Hou, Yi Zhang, Xianli Meng, Xiaobo Wang   +6 more
openaire   +2 more sources

Engineering Escherichia coli for Efficient De Novo Synthesis of Salidroside.

Journal of Agricultural and Food Chemistry
Salidroside is a high-value plant-derived glycoside with diverse biological activities, but the main industrial salidroside production method, extraction from Rhodiola plants, is insufficient to meet the growing market demand.
Weizhu Zeng, Huijing Wang, Jianbin Chen, Minglong Hu, Xinru Wang, Jian Chen, Jingwen Zhou   +6 more
semanticscholar   +1 more source

Salidroside Attenuates LPS-Induced Acute Lung Injury in Rats

Inflammation, 2017
The purpose of the present study was to investigate the effects of salidroside (Sal) on lung injury in lipopolysaccharide (LPS)-induced endotoxemic in vitro and in vivo. SD rats were randomly divided into five groups: control group, LPS group (15 mg kg-1), LPS plus dexamethasone (2 mg kg-1), and LPS plus Sal groups with different Sal doses (20 mg kg-1,
Liu, Jingyan, Guo, Yujuan, Yang, Yiming, Zhu, Lingpeng, Yan, Tianhua, Miao, Mingxing   +5 more
openaire   +2 more sources

Enzymatic Glucosylation of Salidroside from Starch by α-Amylase

Journal of Agricultural and Food Chemistry, 2019
α-Amylases are among the most important and widely used industrial enzymes for starch processing. In this work, an α-amylase from Bacillus subtilis XL8 was purified and found to possess both hydrolysis and transglycosylation activities. The optimal pH and temperature for starch hydrolysis were pH 5.0 and 70 °C, respectively.
Ke Wang, Tingting Qi, Longcheng Guo, Zhongxuan Ma, Guofeng Gu, Min Xiao, Lili Lu   +6 more
openaire   +2 more sources

Salidroside Alleviates Furan-Induced Impaired Gut Barrier and Inflammation via Gut Microbiota-SCFA-TLR4 Signaling.

Journal of Agricultural and Food Chemistry
As a food contaminant that can be quickly absorbed through the gastrointestinal system, furan has been shown to disrupt the intestinal flora and barrier. Investigation of the intestinal toxicity mechanism of furan is of great significance to health.
Ziyue Wang, Lu Li, Wenliang Li, Haiyang Yan, Yuan Yuan   +4 more
semanticscholar   +1 more source

Salidroside Protects Human Erythrocytes against Hydrogen Peroxide-Induced Apoptosis

Journal of Natural Products, 2012
Rhodiola rosea is a commonly used folk medicine for the treatment of high altitude sickness, mountain malhypoxia, and anoxia. Its active ingredient, salidroside [2-(4-hydroxyphenyl)ethyl β-D-glucopyranoside (1)], has been reported to have a broad spectrum of biological effects.
Erin Wei, Qian, Daniel Tianfang, Ge, Siu-Kai, Kong   +2 more
openaire   +2 more sources