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Salidroside improves blood–brain barrier integrity and cognitive function in hypobaric hypoxia mice by inhibiting microglia activation through GSK3β

Phytotherapy Research
Salidroside, an active component found in Rhodiola rosea L., has emerged as a potential therapeutic agent for the prevention and treatment of hypoxic brain injury, while the precise target and mechanism of salidroside were remain unclear.
Xianxie Zhang   +6 more
semanticscholar   +1 more source

Rhodiola and salidroside in the treatment of metabolic disorders

Mini-Reviews in Medicinal Chemistry, 2019
Over the past three decades, the knowledge gained about the mechanisms that underpin the potential use of Rhodiola in stress- and ageing-associated disorders has increased, and provided a universal framework for studies that focused on the use of Rhodiola in preventing or curing metabolic diseases.
Xiang-Li, Bai   +4 more
openaire   +2 more sources

Encapsulation and release of salidroside in myofibrillar protein‑sodium alginate gel: Effects of different M/G ratios of sodium alginate.

International Journal of Biological Macromolecules
Myofibrillar protein‑sodium alginate (MP-SA) gels play a pivotal role in the development of functional food gels. Salidroside (SAL) is promising component but suffers from low bioavailability, necessitating effective delivery systems.
Zerun Zhao   +6 more
semanticscholar   +1 more source

Rhodiola and Salidroside Attenuate Oxidative Stress‐Triggered H9c2 Cardiomyoblast Apoptosis Through IGF1R‐Induced ERK1/2 Activation

Environmental Toxicology
Oxidative stress is a pivotal factor in the pathogenesis of various cardiovascular diseases. Rhodiola, a traditional Chinese medicine, is recognized for its potent antioxidant properties.
I-Ju Ju   +10 more
semanticscholar   +1 more source

Osteoprotective effects of salidroside in ovariectomized mice and diabetic mice

European Journal of Pharmacology, 2018
Salidroside, an active constituent from the root of Rhodiola rosea L., has multiple pharmacological effects, such as anti-cancer, anti-inflammatory and anti-oxidative properties, etc. However, its protective effect on bone tissue via regulating calcium homeostasis is yet to be determined.
Xiang-Fan, Chen   +4 more
openaire   +2 more sources

Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia

Phytotherapy Research
Salidroside, a principal bioactive component of Rhodiola crenulata, is neuroprotective across a wide time window in stroke models. We investigated whether salidroside induced neurogenesis after cerebral ischemia and aimed to identify its primary ...
Wenfang Lai   +7 more
semanticscholar   +1 more source

Salidroside exerts anti-tumor effects in ovarian cancer by inhibiting STAT3/c-Myc pathway-mediated glycolysis

Biomolecules & biomedicine
Salidroside (SAL) is a bioactive substance extracted from the traditional Chinese medicine Rhodiola rosea, which exhibits multiple pharmacological effects, such as anti-inflammatory, antioxidant, and anti-tumor properties.
Ge Yu, Xiaoling Feng
semanticscholar   +1 more source

Ameliorative effect of salidroside on the cyclophosphamide-induced premature ovarian failure in a rat model

Free radical research
Background Oxidative stress injury is an important pathological factor of premature ovarian failure (POF). Salidroside, extracted from the Chinese herb-Rhodiola rosea, has advantages in antioxidant characteristics. However, their therapeutic efficacy and
Lixuan Chen   +5 more
semanticscholar   +1 more source

Synthesis of eutigoside C based on salidroside

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
Eutigoside C has been synthesized starting from commercially available salidroside through a linear reaction sequence of 2 steps with an overall yield of 65.6%. This approach involves selective hydroxy esterification and phenolic hydroxyl oxidation. Up to 11 g of eutigoside C was achieved by this new simple and efficient semi-synthetic strategy, that ...
openaire   +1 more source

Mechanism of salidroside regulating autophagy based on network pharmacology and molecular docking

Anti-Cancer Drugs
Salidroside is a natural product of phenols with a wide range of pharmacological functions, but whether it plays a role in regulating autophagy is unclear.
Yihong Chai   +5 more
semanticscholar   +1 more source

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