Results 61 to 70 of about 7,877 (239)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

Aging, 2020
Parkinson's disease (PD) is a common age-related neurodegenerative movement disorder, which is mainly due to the loss of dopaminergic neurons. Pyroptosis is a new programmed cell death characterized by NLR Family Pyrin Domain Containing 3 (NLRP3)-dependent, IL-1β, IL-18 and Gasdermin D.
Zhang, Xue, Zhang, Yiming, Li, Rui, Zhu, Lingpeng, Fu, Buqing, Yan, Tianhua   +5 more
openaire   +2 more sources

Salidroside mediated stabilization of Bcl -xL prevents mitophagy in CA3 hippocampal neurons during hypoxia

Neurobiology of Disease, 2018
Chronic hypoxic stress results in deposition of lipofuscin granules in the CA3 region of hippocampal neurons which contributes to neurodegeneration and accelerated neuronal aging.
Suryanarayan Biswal, Kalpana Kumari Barhwal, Debashree Das, Richa Dhingra, Nilima Dhingra, Tapas Chanda Nag, Sunil Kumar Hota   +6 more
doaj   +1 more source

A facile and efficient synthesis approach of salidroside esters by whole-cell biocatalysts in organic solvents

Frontiers in Bioengineering and Biotechnology, 2022
Salidroside, the main bioactive compound isolated from the plant source of Rhodiola rosea L, possesses broad-spectrum pharmacological activities, but suffers from the low cell membranes permeability and alimentary absorption due to its high polarity ...
Rongling Yang, Yu Wang, Xiangjie Zhao, Zheng Tong, Qianlin Zhu, Xiaoxi He, Zhaoyu Wang, Hongzhen Luo, Fang Fang   +8 more
doaj   +1 more source

Salidroside Mediated the Nrf2/GPX4 Pathway to Attenuates Ferroptosis in Parkinson’s Disease

Neurochemical Research
Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons, with ferroptosis playing a significant role. Salidroside (SAL) has shown neuroprotective potential, this study aims to explore its capacity to mitigate ferroptosis in PD ...
Jun Shen, Shasha Chen, Xin Li, Lele Wu, Xue Mao, Jingjie Jiang, Dabu Zhu   +6 more
semanticscholar   +1 more source

Protective Effects of Auricularia auricula Polysaccharides on Acute Lung Injury by Regulating Intestinal Flora and Metabolism

Food Frontiers, Volume 7, Issue 2, March 2026.
Auricularia auricula polysaccharides (AAP; 100, 200, and 400 mg/kg) protect against acute lung injury (ALI) by dose‐dependently remodeling the gut microbiota and modulating associated metabolic pathways via the gut‐lung axis, thereby enhancing pulmonary anti‐inflammatory and antioxidant capacity to ultimately prevent tissue damage.
Haili Niu, Fangjia Zhao, Qi Wang, Min Li, Yuan Li, Ivan Kurtovic, Zitong Zhang, Yahong Yuan, Tianli Yue   +8 more
wiley   +1 more source

Engineering salidroside biosynthetic pathway in hairy root cultures of Rhodiola crenulata based on metabolic characterization of tyrosine decarboxylase. [PDF]

PLoS ONE, 2013
Tyrosine decarboxylase initializes salidroside biosynthesis. Metabolic characterization of tyrosine decarboxylase gene from Rhodiola crenulata (RcTYDC) revealed that it played an important role in salidroside biosynthesis.
Xiaozhong Lan, Kai Chang, Lingjiang Zeng, Xiaoqiang Liu, Fei Qiu, Weilie Zheng, Hong Quan, Zhihua Liao, Min Chen, Wenlin Huang, Wanhong Liu, Qiang Wang   +11 more
doaj   +1 more source

Neurocognitive improvement through plant food bioactives: A particular approach to Alzheimer's disease [PDF]

, 2017
Alzheimer’s disease (AD) is currently one of the most prevalent neurodegenerative disorders, directly related to increasing rates of morbidity and autonomy impairment between worldwide citizens. Social and demographical changes are direct contributors;
Ferreira, Isabel C.F.R., Martins, Natália   +1 more
core   +1 more source

Designing Protein Gels for Nutrient Delivery: From Formulation to Digestion

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 2, March 2026.
ABSTRACT Protein gels have diverse applications in food industry, with plant proteins as potential alternatives to animal‐derived products. The applications of protein gels mainly depend on gel properties while gel digestibility affects the delivery and release of nutrients. However, the relationship and synergistic influences among gelation mechanism,
Xue Dong, Yong Wang, Xiao Dong Chen, Cordelia Selomulya   +3 more
wiley   +1 more source

Salidroside Protects Lipopolysaccharide-Induced Acute Lung Injury in Mice [PDF]

Dose-Response, 2016
Salidroside (SDS) has been reported to have anti-inflammatory properties. The objective of this study was to investigate the protective effect of SDS on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. BALB/c mice were pretreated with SDS 1 hour before intranasal instillation of LPS.
Rufeng Lu, Yueguo Wu, Honggang Guo, Xiaomin Huang   +3 more
openaire   +3 more sources