Results 71 to 80 of about 7,877 (239)

Salidroside overcomes dexamethasone resistance in T‑acute lymphoblastic leukemia cells

Experimental and Therapeutic Medicine, 2021
The aim of the present study was to analyze whether the use of salidroside (SAL) could overcome dexamethasone (DEX) resistance in T-acute lymphocytic leukemia cells. The human T-ALL DEX-resistant cell line, CEM-C1 and the DEX-sensitive cell line, CEM-C7 were used in the current study.
Niu, Ya-Na, Zeng, Yan, Zhong, Fang-Fang, Long, Si-Li, Ren, Dan-Wei, Qin, Xiang, Liu, Wen-Jun   +6 more
openaire   +3 more sources

Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases [PDF]

, 2015
Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society.
A Gutierrez-Zepeda, A Hornsten, A Lublin, A Murakami, A Tauffenberger, A Teixeira-Castro, A Teixeira-Castro, A Vaccaro, Alan Morgan, AR Burns, AV McCormick, B Lakowski, B Wolozin, BA Benitez, BB Kautu, BC Kraemer, BH Shin, BP Hubbard, C Fatouros, C Frokjaer-Jensen, C Soto, C Voisine, C Yao, CD Link, CD Link, CD Link, CD Link, CI Nussbaum-Krammer, CJ Locke, CY Ewald, D Levitan, DC Swinney, DC Swinney, DE Ehrnhoefer, DF Silva, DF Tardiff, DP Karpinar, DS Fay, E Braungart, EM Mandelkow, F Aparecida Paiva, F Cabreiro, F-X Lejeune, G McColl, G Pani, H Varma, H Wang, H Witan, HR Brignull, HV McCue, J Drake, J Li, J Liu, J Parker, J Parker, J Sämann, J Wang, JA Baur, JA Hardaway, Jeff W. Barclay, JF Morley, JN Sleigh, JP Taylor, JS Sangha, JV Smith, JW Barclay, K Evason, K Yamanaka, K-W Park, KA Caldwell, KE Matlack, L Diomede, L Diomede, L Noskova, L Xiao, LE Dosanjh, LS Schneider, M Briese, M Cadieux-Dion, M Haltia, M Haltia, M Lakso, M Marvanova, M Velinov, ML Florez-McClure, N Bizat, N Bizat, N Wittenburg, NF Liachko, NF Liachko, NT Christie, P Haldimann, PE Ash, PJ Muchowski, PW Faber, Q Ruan, R Brandt, R Keowkase, R Nass, R Nass, R Ved, R-H Fu, R-H Fu, RA Weiss, RD Burgoyne, Robert D. Burgoyne, S Abbas, S Abbas, S Alavez, S Amor, S Ayyadevara, S Buttner, S Cao, S Hamamichi, S Jagota, S Saha, S Treusch, SH Satyal, SJ Park, SM Yatin, SS Karuppagounder, SS Kashyap, T Gidalevitz, T Ham van, T Kuwahara, T Kuwahara, T Kuwahara, T Miyasaka, T Oeda, T Zhang, TJ Ham van, TT Ching, U Arya, V Crunelli, V Dostal, W Springer, X Chen, X Chen, X Yang, Xi Chen, Y Wu, Z Liu   +141 more
core   +1 more source

Spatial heterogeneity in microglia‐complement crosstalk: Implications for synaptic pruning in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss, as a key pathological feature in its early stages. Recent studies have highlighted the central role of microglia–complement interactions in synaptic pruning.
Qiuyan Ye, Wei Gao, Jiaping Feng, Xue Li, Jianhui Li, Fengge Yang, Linqing Li, Mingsheng Zi, Xinkai Wu, Hainan Gao, Honglin Li   +10 more
wiley   +1 more source

Antagonistic Effect of Salidroside on Podocyte Pyroptosis in Diabetic Kidney Disease Rats under Hypoxia Based on NLRP3/IL-1β/TGF-β1 Pathway [PDF]

Zhongguo quanke yixue
Background Salidroside has been shown to protect diabetic kidney disease (DKD) rats, however, whether it is equally effective in a hypoxic environment and the specific mechanism of action remain unclear. Objective To observe the effects of salidroside on
LI Jiawu, QIN Feng, SONG Shengqin, ZHAI Tin, XIN Hongyun, BA Yinggui
doaj   +1 more source

The cardiovascular effects of salidroside in the Goto-Kakizaki diabetic rat model [PDF]

, 2015
Many factors, including hyperglycemia, hypertension, obesity, dyslipidemia, and a sedentary lifestyle, contribute to a high prevalence of cardiovascular disease. Specific vascular impairment treatments in the context of diabetes and vascular risk need to
A. Alameddine, A. Ayer, D. Gauguier, G. Gauquelin-Koch, J. Bourreau, M. Yuan, M.A. Custaud, N. Navasiolava, S. Derbré, Z. Fajloun   +9 more
core   +1 more source

Stress-induced reinstatement of nicotine preference requires dynorphin/kappa opioid activity in the basolateral amygdala [PDF]

, 2016
UNLABELLED: The dynorphin (DYN)/kappa-opioid receptor (KOR) system plays a conserved role in stress-induced reinstatement of drug seeking for prototypical substances of abuse.
Bruchas, Michael R, Carlezon, William A, Hourguettes, Nicholas J, Nygard, Stephanie K, Sobczak, Gabe G   +4 more
core   +2 more sources

Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr., Georgii B. Telegin, Aleksandr S. Chernov, Anna A. Kudriaeva, Alexey N. Minakov, Maksim V. Rodionov, Vitaly A. Kazakov, Viktor A. Palikov, Yuri M. Poluektov, Rustam H. Ziganshin, Daria A. Orlova, Alena S. Evpak, Daniil A. Barsuk, Fedor A. Mesheryakov, Aldo Spallone, Dmitry S. Asyutin, Igor N. Pronin, Nikolay A. Konovalov, Dmitri Yu Usachev, Alexander G. Gabibov, Alexander N. Konovalov   +20 more
wiley   +1 more source

Salidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury.

PLoS ONE, 2012
BackgroundTraumatic brain injury (TBI) induces a complex sequence of apopototic cascades that contribute to secondary tissue damage. The aim of this study was to investigate the effects of salidroside, a phenolic glycoside with potent anti-apoptotic ...
Szu-Fu Chen, Hsin-Ju Tsai, Tai-Ho Hung, Chien-Cheng Chen, Chao Yu Lee, Chun-Hu Wu, Pei-Yi Wang, Nien-Chieh Liao   +7 more
doaj   +1 more source

Lipid-coated polymeric nanoparticles for cancer drug delivery [PDF]

, 2015
Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers.
Alphonso, Anderson, Aravind, Aryal, Brouet, Chan, Clawson, Clevers, Copp, Danhier, De Miguel, Deok Kong, Desimone, Dong, Fang, Ferenz, Fickweiler, Frangioni, Gao, Gao, Gobin, Gold, Gomer, Gottesman, Gref, Hasan, Heidenreich, Hu, Hu, Huang, Ishimoto, Islam, Jia, Joyce, Joyce, Kevin, Koch, Kolhar, Kumar, Lee, Levine, Li, Liao, Liechty, Lim, Liu, Liu, Liu, Marino, Mastrobattista, Mieszawska, Mohindra, Nelson, Norris, Palange, Park, Peer, Poste, Prasad, Reid, Sengupta, Sharma, Shi, Shi, Siemann, Steinbach, Su, Su, Tanjore, Thevenot, Troutier, Troutier, van Vlerken, Wang, Wang, Weigelt, Werner, Willem, Wong, Wong, Wong, Yang, Yang, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zheng   +89 more
core   +1 more source

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source