Results 71 to 80 of about 786,214 (299)
CB1 Receptor Antagonism Blocks Stress-Potentiated Reinstatement of Cocaine Seeking in Rats [PDF]
, 2015 Rationale Under some conditions, stress, rather than directly triggering cocaine seeking, potentiates reinstatement to other stimuli, including a subthreshold cocaine dose.
Baker, David A. +6 more
core +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
PlantsSoil salinization poses a significant threat to global agricultural productivity. Among crops, soybean (Glycine max), an important source of oil and protein, is more susceptible to salt stress compared to other major crops such as wheat (Triticum ...
Tingjia Dong +4 more
doaj +1 more source
Thermal effects on geologic carbon storage [PDF]
, 2017 The final publication is available at Springer via http://dx.doi.org/10.1016/j.earscirev.2016.12.011One of the most promising ways to significantly reduce greenhouse gases emissions, while carbon-free energy sources are developed, is Carbon Capture and ...
Rutqvist, Jonny +1 more
core +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
PlantsFreshwater depletion becomes a significant challenge as the population grows and food demand rises. We evaluated the responses of lettuce cultivars (Lactuca Sativa) under saline stress in photosynthetic responses, production, and ion homeostasis. We used
Jussiara Sonally Jácome Cavalcante +12 more
doaj +1 more source
secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila [PDF]
, 2019 Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products.
Dent, J. +6 more
core +2 more sources
Biotechnology of water and salinity stress tolerance [PDF]
Current Opinion in Biotechnology, 2010 Drought and salinity are among the environmental factors that constrain agricultural productivity most dramatically. Classical breeding programs aiming to improve stress tolerance have been hampered by the multigenic nature of the trait and the seemingly scarce natural genetic variability in crop plants.
openaire +3 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source