Results 71 to 80 of about 8,399,787 (287)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Instability of the salinity profile during the evaporation of saline groundwater [PDF]

, 2008
We investigate salt transport during the evaporation and upflow of saline groundwater. We describe a model in which a sharp evaporation-precipitation front separates regions of soil saturated with an air-vapour mixture and with saline water.
Pritchard, David, Il'ichev, Andrej T., Richardson, Chris N., Tsypkin, George G.   +3 more
core   +4 more sources

CmRAV1 shows differential expression in two melon (Cucumis melo L.) cultivars and enhances salt tolerance in transgenic Arabidopsis plants

Acta Biochimica et Biophysica Sinica, 2019
The growth and development of melon (Cucumis melo L.) are severely affected by soil salinization in many areas of the world, but the understanding of the molecular mechanisms underlying salt tolerance in melon remains limited.
Zhao Lina, Zhang Furong, Liu Bin, Yang Senlin, Xiong Xue, Hassani Danial, Zhang Yidong   +6 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Molecular drivers and physiological consequences of saline-alkaline stress resilience in the large-scale loach (Paramisgurnus dabryanus)

Ecotoxicology and Environmental Safety
The development of saline-alkaline tolerant fish species has received extensive attention as a strategy for expanding aquaculture into inland saline-alkaline waters to optimize land use efficiency.
Ran Xu, Gaofeng Peng, Wei Wang, Jing Du, Yunlong Zhang   +4 more
doaj   +1 more source

Viabilidade da irrigação do meloeiro com águas salinas em diferentes fases fenológicas Feasibility of irrigation of musk melon with salinity water in different phenological stages

Ciência Rural, 2006
Com o objetivo de estudar os efeitos da aplicação de águas de irrigação de diferentes salinidades no rendimento do melão irrigado por gotejamento e de associar a produção obtida com o custo da água utilizada, desenvolveu-se este trabalho em Mossoró-RN ...
Francisco de Queiroz Porto Filho, José Francismar de Medeiros, Eduardo Rodrigues de Sousa Neto, Hans Raj Gheyi, José de Arimatea de Matos   +4 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The WD40 gene family in recretohalophyte Limonium bicolor: genomic identification and functional analysis in salt gland development and salinity tolerance

Frontiers in Plant Science
IntroductionDeveloping salt-tolerant crops is critical for utilizing saline soils in agriculture. Limonium bicolor, a recretohalophyte with epidermal salt glands, represents a valuable genetic resource for salt tolerance engineering.
Lu Sun, Huiying Mu, Yuqing Tan, Baoshan Wang, Xi Wang, Xi Wang, Fang Yuan, Fang Yuan   +7 more
doaj   +1 more source