Results 71 to 80 of about 947,047 (350)

Predicting long-term dynamics of soil salinity and sodicity on a global scale

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Land degradation due to soil salinization has detrimental impacts on vegetation, crops, and human livelihoods, leading to a need for a methodologically consistent analysis of the variability of different aspects of salt-affected soils ...
Amirhossein Hassani, A. Azapagic, N. Shokri   +2 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Impact of water deficit (salt and drought) stress on physiological, biochemical and yield attributes on wheat (Triticum aestivum) varieties

The Indian Journal of Agricultural Sciences, 2018
This investigation was carried out to assess the combined effect of salt stress and drought on physiological and biochemical traits in wheat (Triticum aestivum L.) varieties so as to deduce the probable mechanism of stress tolerance in these varieties ...
ASHWANI KUMAR, SURINDER KUMAR SHARMA, CHARU LATA, RITU DEVI, NEERAJ KULSHRESTHA, S L KRISHNAMURTHY, KAILASH SINGH, RAJENDER KUMAR YADAV   +7 more
doaj   +1 more source

Soil Salinity: Effect on Vegetable Crop Growth. Management Practices to Prevent and Mitigate Soil Salinization

, 2017
Salinity is a major problem affecting crop production all over the world: 20% of cultivated land in the world, and 33% of irrigated land, are salt-affected and degraded.
R. Machado, R. Serralheiro
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Different Soil Salinity Imparts Clear Alteration in Rhizospheric Bacterial Community Dynamics in Rice and Peanut. [PDF]

, 2021
Md Majharul Islam, Rajarshi Bhattacharya, Biraj Sarkar, Pulak Kumar Maiti, Shouvik Mahanty, Punarbasu Chaudhuri, Swadesh Ranjan Biswas, Sukhendu Mandal   +7 more
openalex   +1 more source

An Overview of Hazardous Impacts of Soil Salinity in Crops, Tolerance Mechanisms, and Amelioration through Selenium Supplementation

International Journal of Molecular Sciences, 2019
Soil salinization is one of the major environmental stressors hampering the growth and yield of crops all over the world. A wide spectrum of physiological and biochemical alterations of plants are induced by salinity, which causes lowered water potential
M. Kamran, Aasma Parveen, Sunny Ahmar, Z. Malik, S. Hussain, Muhammad Sohaib Chattha, M. Saleem, M. Adil, P. Heidari, J. Chen   +9 more
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Prolonged alkali water irrigation: impacts of treatment strategies on soil health and microbial dynamics

Ecological Processes
Background The extent of natural salt-laden groundwaters used for irrigation is increasing worldwide, which is a fast-emerging threat to agroecosystems and global food security.
Kirti Yadav, Awtar Singh, Neeraj K. Aggarwal, Gajender Yadav, Nirmalendu Basak, Ajay Kumar Bhardwaj, Rajender Kumar Yadav   +6 more
doaj   +1 more source