Results 61 to 70 of about 169,118 (334)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Journal of Hydrology: Regional StudiesStudy region: The Songnen Plain is a key part of China’s largest plain, situated in northeastern China. Study focus: Soil salinization has become one of the largest ecological issues in the Songnen Plain, and regulating groundwater levels is a crucial ...
Yiding Ding +8 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
LandSoil salinization is a critical global environmental issue, exacerbated by climatic and anthropogenic factors, and posing significant threats to agricultural productivity and ecological stability in arid regions.
Shiqin Li +5 more
doaj +1 more source
Draft genome sequence of Frankia sp. strain BMG5.23, a salt-tolerant nitrogen-fixing actinobacterium isolated from the root nodules of Casuarina glauca grown in Tunisia [PDF]
, 2014 Nitrogen-fixing actinobacteria of the genus Frankia are symbionts of woody dicotyledonous plants termed actinorhizal plants. We report here a 5.27-Mbp draft genome sequence for Frankia sp.
Abebe-Akele, Feseha +9 more
core +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Spatial Distribution and Temporal Evolution of Soil Salinization in the Oasis Irrigated Area
AgronomySalinization of irrigation areas is a key environmental challenge faced by arid and semi-arid regions worldwide, and the complexity of natural environment and human activities increases the uncertainty of salinization distribution.
Tingbo Lv +5 more
doaj +1 more source
Seasonal Salinization Decreases Spatial Heterogeneity of Sulfate Reducing Activity
Soil Systems, 2019 Evidence of sulfate input and reduction in coastal freshwater wetlands is often visible in the black iron monosulfide (FeS) complexes that form in iron rich reducing sediments.
Valerie A. Schoepfer +3 more
doaj +1 more source
Knowledge and perceptions in participatory policy processes: lessons from the delta-region in the Netherlands [PDF]
, 2008 Water resources management issues tend to affect a variety of uses and users. Therefore, they often exhibit complex and unstructured problems. The complex, unstructured nature of these problems originates from uncertain knowledge and from the existence ...
Bouma, Geiske +3 more
core +2 more sources