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Prognostic value of integrating circulating tumour cells and cell-free DNA in non-small cell lung cancer

open access: yesHeliyon, 2022
Background: Non-small cell lung cancer (NSCLC) often presents at an incurable stage, and majority of patients will be considered for palliative treatment at some point in their disease.
Joanna Kapeleris   +11 more
doaj   +1 more source

Promising applications of human-derived saliva biomarker testing in clinical diagnostics

open access: yesInternational Journal of Oral Science, 2023
Saliva testing is a vital method for clinical applications, for its noninvasive features, richness in substances, and the huge amount. Due to its direct anatomical connection with oral, digestive, and endocrine systems, clinical usage of saliva testing ...
Mengyuan Song   +4 more
doaj   +1 more source

Salivary exosomes as biomarkers for early diagnosis of oral squamous cell carcinoma

open access: yesOral Oncology Reports, 2023
Introduction: Due to late diagnosis, prognosis is poor for patients with oral squamous cell carcinoma (OSCC). Saliva is in close proximity to tumours originating from the oral cavity and by profiling exosomes derived from saliva can be used as biomarkers
Natalie Bozyk   +6 more
doaj   +1 more source

DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers

open access: yesCells, 2020
Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile.
Chameera Ekanayake Weeramange   +5 more
doaj   +1 more source

Salivary micro RNAs as biomarkers for oropharyngeal cancer

open access: yesCancer Medicine, 2023
Background Despite the rising incidence, particularly of the human papillomavirus (HPV)‐associated fraction of oropharyngeal cancer (OPC), there are no early detection methods for OPC.
Chameera Ekanayake Weeramange   +10 more
doaj   +1 more source

The salivary metatranscriptome as an accurate diagnostic indicator of oral cancer

open access: yesnpj Genomic Medicine, 2021
Despite advances in cancer treatment, the 5-year mortality rate for oral cancers (OC) is 40%, mainly due to the lack of early diagnostics. To advance early diagnostics for high-risk and average-risk populations, we developed and evaluated machine ...
Guruduth Banavar   +16 more
doaj   +1 more source

Circulating tumour DNA alterations: emerging biomarker in head and neck squamous cell carcinoma

open access: yesJournal of Biomedical Science, 2023
Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract cancer and account for 931,922 new cases and 467,125 deaths worldwide. About 90% of these cancers are of squamous cell origin (HNSCC).
Xiaomin Huang   +7 more
doaj   +1 more source

Volume minimum saliva untuk deteksi Human Beta Globin sebagai penanda DNA Genom Manusia

open access: yesJKS (Jurnal Kedokteran Syiah Kuala), 2023
Saliva can be a source of DNA since it contains human cells from the oral mucosa. In addition, saliva contains a variety of normal flora. Recently, saliva has become important as a diagnostic fluid. Saliva is an easily accessible fluid that is similar to
Zulham Yamamoto   +2 more
doaj   +1 more source

Stimulated Parotid Saliva Is a Better Method for Depression Prediction

open access: yesBiomedicines, 2022
Background: Saliva cortisol is considered to be a biomarker of depression prediction. However, saliva collection methods can affect the saliva cortisol level.
Yangyang Cui   +6 more
doaj   +1 more source

Saliva TwoStep for rapid detection of asymptomatic SARS-CoV-2 carriers

open access: yeseLife, 2021
Here, we develop a simple molecular test for SARS-CoV-2 in saliva based on reverse transcription loop-mediated isothermal amplification. The test has two steps: (1) heat saliva with a stabilization solution and (2) detect virus by incubating with a ...
Qing Yang   +24 more
doaj   +1 more source

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