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Promising applications of human-derived saliva biomarker testing in clinical diagnostics

open access: yesInternational Journal of Oral Science, 2023
Saliva testing is a vital method for clinical applications, for its noninvasive features, richness in substances, and the huge amount. Due to its direct anatomical connection with oral, digestive, and endocrine systems, clinical usage of saliva testing ...
Mengyuan Song   +4 more
doaj   +2 more sources

A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma

open access: yesNature Biomedical Engineering, 2022
Rapid, accurate and frequent detection of the RNA of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and of serological host antibodies to the virus would facilitate the determination of the immune status of individuals who have Coronavirus ...
Devora A Najjar   +2 more
exaly   +2 more sources

Consistent Detection of 2019 Novel Coronavirus in Saliva

open access: yesClinical Infectious Diseases, 2020
The 2019 novel coronavirus (2019-nCoV) was detected in the self-collected saliva of 91.7% (11/12) of patients. Serial saliva viral load monitoring generally showed a declining trend. Live virus was detected in saliva by viral culture.
Kelvin Kai-Wang To   +2 more
exaly   +2 more sources

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

open access: yesScience Immunology, 2020
Saliva is an alternative biofluid to serum for detecting and monitoring IgG to SARS-CoV-2 spike and RBD antigens in COVID-19. While the antibody response to SARS-CoV-2 has been extensively studied in blood, relatively little is known about the antibody ...
Baweleta Isho   +2 more
exaly   +2 more sources

Saliva: potential diagnostic value and transmission of 2019-nCoV

open access: yesInternational Journal of Oral Science, 2020
2019-nCoV epidemic was firstly reported at late December of 2019 and has caused a global outbreak of COVID-19 now. Saliva, a biofluid largely generated from salivary glands in oral cavity, has been reported 2019-nCoV nucleic acid positive. Besides lungs,
Ruoshi Xu, Xiaobo Duan, Xuedong Zhou
exaly   +2 more sources

SARS-CoV-2 infection of the oral cavity and saliva

open access: yesNature Medicine, 2021
Blake M Warner, Takafumi Kato, Yu Mikami
exaly   +2 more sources

Saliva Based Clozapine Therapeutic Drug Monitoring: A Systematic Review [PDF]

open access: yesPharmacology Research & Perspectives
Clozapine is superior in the treatment of treatment‐refractory schizophrenia but requires therapeutic drug monitoring (TDM) due to its unpredictable pharmacokinetics and dose‐dependent side effects.
Tessa Rademaker   +4 more
doaj   +2 more sources

Evaluating the use of posterior oropharyngeal saliva in a point-of-care assay for the detection of SARS-CoV-2

open access: yesEmerging Microbes and Infections, 2020
During the Coronavirus disease 2019 (COVID-19) pandemic, logistic problems associated with specimen collection limited the SARS-CoV-2 testing, especially in the community.
Jonathan Hon-Kwan Chen   +8 more
doaj   +2 more sources

Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2: A Systematic Review and Meta-analysis.

open access: yesJAMA Internal Medicine, 2021
Importance Nasopharyngeal swab nucleic acid amplification testing (NAAT) is the noninvasive criterion standard for diagnosis of coronavirus disease 2019 (COVID-19). However, it requires trained personnel, limiting its availability. Saliva NAAT represents
G. Butler-Laporte   +6 more
semanticscholar   +1 more source

Prognostic value of integrating circulating tumour cells and cell-free DNA in non-small cell lung cancer

open access: yesHeliyon, 2022
Background: Non-small cell lung cancer (NSCLC) often presents at an incurable stage, and majority of patients will be considered for palliative treatment at some point in their disease.
Joanna Kapeleris   +11 more
doaj   +1 more source

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