Erosion protection conferred by whole human saliva, dialysed saliva, and artificial saliva. [PDF]
Scientific Reports, 2016 During dental erosion, tooth minerals are dissolved, leading to a softening of the surface and consequently to irreversible surface loss. Components from human saliva form a pellicle on the tooth surface, providing some protection against erosion.
Baumann, Tommy +3 more
core +5 more sources
Stimulated and unstimulated saliva samples have significantly different bacterial profiles [PDF]
PLoS ONE, 2018 Epidemiological studies use saliva on a regular basis as a non-invasive and easy-to-take sample, which is assumed to be a microbial representative of the oral cavity ecosystem.
Aurea Simón-Soro +2 more
exaly +2 more sources
Saliva diagnostics: Salivaomics, saliva exosomics, and saliva liquid biopsy. [PDF]
Journal of the American Dental Association (1939), 2023 Each day, humans produce approximately 0.5 through 1.5 liters of saliva, a biofluid that is rich in biological omic constituents. Our lack of understanding how omic biomarkers migrate from diseased tissue to the saliva has impeded the clinical translation of saliva testing.
Nonaka, Taichiro, Wong, David TW
openaire +7 more sources
Heliyon, 2022 Background: Non-small cell lung cancer (NSCLC) often presents at an incurable stage, and majority of patients will be considered for palliative treatment at some point in their disease.
Joanna Kapeleris +11 more
doaj +1 more source
Promising applications of human-derived saliva biomarker testing in clinical diagnostics
International Journal of Oral Science, 2023 Saliva testing is a vital method for clinical applications, for its noninvasive features, richness in substances, and the huge amount. Due to its direct anatomical connection with oral, digestive, and endocrine systems, clinical usage of saliva testing ...
Mengyuan Song +4 more
doaj +1 more source
Salivary exosomes as biomarkers for early diagnosis of oral squamous cell carcinoma
Oral Oncology Reports, 2023 Introduction: Due to late diagnosis, prognosis is poor for patients with oral squamous cell carcinoma (OSCC). Saliva is in close proximity to tumours originating from the oral cavity and by profiling exosomes derived from saliva can be used as biomarkers
Natalie Bozyk +6 more
doaj +1 more source
The salivary metatranscriptome as an accurate diagnostic indicator of oral cancer
npj Genomic Medicine, 2021 Despite advances in cancer treatment, the 5-year mortality rate for oral cancers (OC) is 40%, mainly due to the lack of early diagnostics. To advance early diagnostics for high-risk and average-risk populations, we developed and evaluated machine ...
Guruduth Banavar +16 more
doaj +1 more source
DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers
Cells, 2020 Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile.
Chameera Ekanayake Weeramange +5 more
doaj +1 more source
Salivary micro RNAs as biomarkers for oropharyngeal cancer
Cancer Medicine, 2023 Background Despite the rising incidence, particularly of the human papillomavirus (HPV)‐associated fraction of oropharyngeal cancer (OPC), there are no early detection methods for OPC.
Chameera Ekanayake Weeramange +10 more
doaj +1 more source
Circulating tumour DNA alterations: emerging biomarker in head and neck squamous cell carcinoma
Journal of Biomedical Science, 2023 Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract cancer and account for 931,922 new cases and 467,125 deaths worldwide. About 90% of these cancers are of squamous cell origin (HNSCC).
Xiaomin Huang +7 more
doaj +1 more source