Results 21 to 30 of about 140,151 (307)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Reptes del sistema de salut de Catalunya [PDF]

Revista d'Estudis Autonòmics i Federals
Com podem fer efectiva la protecció del dret a la salut a Catalunya durant els propers anys? Com podem garantir-ne el compliment en totes les seves vessants?
Miquel Casares Roca
doaj   +1 more source

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source

KIF5A p.Pro986Leu Risk Variant and Accelerated Progression of Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study explored the impact of KIF5A rs113247976 (p.Pro986Leu), a risk allele for amyotrophic lateral sclerosis (ALS), on phenotypic variability in two Italian ALS cohorts (discovery, n = 865; replication, n = 1174). The minor allele (T) frequency was 0.015.
Arianna Manini, Rosario Vasta, Alberto Brusati, Francesco Scheveger, Silvia Peverelli, Alessio Maranzano, Alberto Doretti, Francesco Gentile, Eleonora Colombo, Maura Brunetti, Cristina Moglia, Antonio Canosa, Umberto Manera, Maurizio Grassano, Davide Gentilini, Stefano Messina, Federico Verde, Claudia Morelli, John E. Landers, Bryan J. Traynor, Adriano Chiò, Vincenzo Silani, Andrea Calvo, Antonia Ratti, Nicola Ticozzi   +24 more
wiley   +1 more source

Fibronectin modulates the endocannabinoid system through the cAMP/PKA pathway during human sperm capacitation [PDF]

, 2019
Fibronectin (Fn) enhances human sperm capacitation via the cAMP/PKA pathway, and the endocannabinoid system participates in this process. Moreover, Fn has been linked to endocannabinoid system components in different cellular models, even though no ...
Díaz, Emilce Silvina, Kong, Milene, Martínez León, Eduardo Antonio, Morales, Patricio, Osycka Salut, Claudia Elena, Perez Martinez, Silvina Laura, Signorelli, Janetti   +6 more
core   +1 more source

Bona salut a Cuneo. Transformació fluida d'un sistema sanitari local mitjançant la innovació i la col.laboració

Temes de Disseny, 2009
Bona Salut a Cuneo és un projecte d'innovació sanitària que es va posar en marxa l'estiu del 2008 per al sistema regional italià de salut ASL CN1. El projecte proposava noves solucions i estratègies de disseny que volien donar resposta a les necessitats ...
Lekshmy Parameswaran, Laszlo Herczegh
doaj   +4 more sources

INNOVACIONS METODOLOGIQUES: L’ ÚS D’ INSTAGRAM COM A EINA INVESTIGATIVA EN SALUT JUVENIL.

Mètode Science Studies Journal: Annual Review, 2016
La comunicació és clau a l’àmbit de la salut, i incrementa la seva importància amb l’era digital. Internet i els nous mass media esdevenen eines bàsiques de comunicació, essent inclús imprescindibles quan parlem del jovent.
Natàlia Carceller-Maicas
doaj   +1 more source

Myostatin Levels in SMA Following Disease‐Modifying Treatments: A Multi‐Center Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study investigated myostatin levels in SMA patients receiving disease‐modifying therapies (DMTs) to understand their relationship with treatment duration and functional status. Methods Our study includes both cross‐sectional and longitudinal analyses of myostatin levels in treated SMA patients.
Fiorella Piemonte, Sara Petrillo, Anna Capasso, Giorgia Coratti, Adele D'Amico, Michela Catteruccia, Maria Carmela Pera, Concetta Palermo, Marika Pane, Emanuela Abiusi, Gianpaolo Cicala, Marianna Villa, Chiara Bravetti, Chiara Arpaia, Agnese Novelli, Salvatore Falqui, Stefania Fiori, Giulia Napoli, Silvia Baroni, Francesco Danilo Tiziano, Enrico Bertini, Giacomo Comi, Stefania Corti, Eugenio Mercuri   +23 more
wiley   +1 more source

Els casos clínics en català: vitalitat i propostes

Treballs de Sociolingüística Catalana, 2021
Els professionals de la salut disposen d’un gènere per a narrar les experiències clíniques dels seus pacients, amb finalitats didàctiques i de recerca. És el cas clínic (CC), un tipus de relat altament especialitzat i amb unes característiques retòriques
Adéla Ko?átková
doaj  

Correction to: Relational continuity with primary and secondary care doctors: a qualitative study of perceptions of users of the Catalan national health system

BMC Health Services Research, 2018
Following publication of the original article [1], the authors reported a correction in affiliation of Maria Luisa Vázquez, who is affiliated with Health Policy and Health Services Research Group, which is number 1 instead of being affiliated with Grup ...
Sina Waibel, Ingrid Vargas, Jordi Coderch, María-Luisa Vázquez   +3 more
doaj   +1 more source