Results 211 to 220 of about 5,932,890 (256)

Formal total synthesis of salvianolic acid N

Organic & Biomolecular Chemistry, 2018
Salvianolic acid N was synthesized starting from 3,4-dimethoxybenzaldehyde in 11 steps and with an overall yield of 11%. The key reaction steps were the Wittig reaction for Z-stereoselectivity, the copper catalyzed intramolecular cyclization for seven membered ring skeleton, and the deprotected allylic group with Pd catalysis.
Kong Wu, Zhong Pao Xie, Dong-Mei Cui, Chen Zhang   +3 more
openaire   +2 more sources

Salvianolic acid B inhibits hepatic stellate cell activation and liver fibrosis by targeting PDGFRβ.

International Immunopharmacology, 2023
Liver fibrosis is a reversible pathological process and a wound healing response to liver injury. As an early stage of various liver diseases, liver fibrosis can develop into cirrhosis, liver failure, and even liver cancer if not controlled in time ...
Fangbin Liu, Shengnan Li, Panpan Chen, Yanqiu Gu, Shaozhan Wang, Lei Wang, Chun Chen, Rong Wang, Yongfang Yuan   +8 more
semanticscholar   +1 more source

Salvianolic acid A diminishes LDHA‐driven aerobic glycolysis to restrain myofibroblasts activation and cardiac fibrosis via blocking Akt/GSK‐3β/HIF‐1α axis

Phytotherapy Research, 2023
Myofibroblasts activation intensively contributes to cardiac fibrosis with undefined mechanism. Salvianolic acid A (SAA) is a phenolic component derived from Salvia miltiorrhiza with antifibrotic potency.
Renaguli Hailiwu, Hao Zeng, Meiling Zhan, Ting Pan, Hua Yang, Ping Li   +5 more
semanticscholar   +1 more source

Research progress on salvianolic acids of Salvia miltiorrhiza

China Journal of Chinese Materia Medica, 2016
Salvia miltiorrhiza is one of the most common traditional Chinese medicines. It has rich resources in China. According to modern studies, phenolic acids are the main effective components in S. miltiorrhiza. These components have cardiovascular and cerebrovascular protective effect, and anti-tumor, antioxidant, anti-inflammatory, and antifibrotic ...
Wen-Yi, Liang, Wen-Jing, Chen, Guang-Hui, Yang, Dan, Zhu, Xin, Mao, Yan-Yan, Shao, Ling-Fang, Wu, Xiao-Xue, Zhang, Lan-Zhen, Zhang   +8 more
openaire   +2 more sources

Antiplatelet and antithrombotic activities of salvianolic acid A

Thrombosis Research, 2010
Salvianolic acid A (SAA), the water-soluble phenolic acids in Salvia miltiorrhiza, has shown the most potent bioactivities, including protection against cerebral lesion, defense from oxidative damage and improvement of remembrance. In the present study, we studied the antiplatelet and antithrombotic effects of a newly synthesized SAA with different ...
Hua-Ying, Fan, Feng-Hua, Fu, Ming-Yan, Yang, Hui, Xu, Ai-Hong, Zhang, Ke, Liu   +5 more
openaire   +2 more sources

Bioavailability of salvianolic acid B and effect on blood viscosities after oral administration of salvianolic acids in beagle dogs

Archives of Pharmacal Research, 2009
Salvianolic acid B (SalB) is an active component isolated from Chinese herbal medicine Salvia miltiorrhiza. The aim of this study was to investigate the extent of absolute oral bioavailability (F) of SalB in beagle dogs and the effect on blood viscosity after intravenous and oral administration of Salvianolic acids (SAs). A gradient elution HPLC method
Dong-Yan, Gao, Li-Mei, Han, Li-Hong, Zhang, Xiao-Ling, Fang, Jian-Xin, Wang   +4 more
openaire   +2 more sources

The total synthesis of salvianolic acid F

Tetrahedron, 1999
Abstract An expeditious synthesis of salvianolic acid F 2 is described in 10% overall yield. Tetramethyl salvianolic acid F 3 was obtained in six steps in 39% overall yield and was converted into the target molecule using boron tribromide in 26% yield.
Vincent Dalla, Philippe Cotelle
openaire   +1 more source

The transcription factor Dof32 coordinates salvianolic acid biosynthesis and drought tolerance in Salvia miltiorrhiza.

Plant Physiology
Drought severely impacts plant growth, yet moderate drought stress can stimulate the biosynthesis of active compounds in medicinal plants. However, the molecular regulators and mechanisms linking drought resistance with the accumulation of active ...
Bingbing Lv, Qiaoqiao Feng, Gaige Shao, Anqi Zuo, Xuejiao Yan, Jingying Liu, Juane Dong, Pengda Ma   +7 more
semanticscholar   +1 more source

Salvianolic acid A attenuates arsenic-induced ferroptosis and kidney injury via HIF-2α/DUOX1/GPX4 and iron homeostasis.

Science of the Total Environment, 2023
Arsenic (As) is a prevalent pollutant in the environment and causes a high frequency of kidney disease in areas of high arsenic contamination, but its pathogenic mechanisms have yet to be completely clarified.
Desheng Yang, Xinyu Xia, Shuhua Xi
semanticscholar   +1 more source

A quality marker study on salvianolic acids for injection

Phytomedicine, 2018
The quality of Chinese medicine (CM) has being an active and challenging research area for CM. Prof. Chang-Xiao Liu et al first proposed the concept of quality marker (Q-Marker) for the quality evaluation and control on CM. This article describe the exploratory studies of Q-Marker in salvianolic acids for injection (SAI) based on this new concept.This ...
Wei, Li, Navaneethakrishnan, Polachi, Xiangyang, Wang, Yang, Chu, Yuan, Wang, Meng, Tian, Dekun, Li, Dazheng, Zhou, Shuiping, Zhou, Aichun, Ju, Yubo, Li, Yanjun, Zhang, Min, Chen, Luqi, Huang, Changxiao, Liu   +14 more
openaire   +2 more sources