Results 221 to 230 of about 5,932,890 (256)

Salvianolic acid B protects against UVB-induced skin aging via activation of NRF2.

Phytomedicine
BACKGROUND Prolonged exposure to sun radiation may result in harmful skin photoaging. Therefore, discovering novel anti-photoaging treatment modalities is critical.
Jia-Ming Sun, Yuxin Liu, Yang-Dan Liu, Chiakang Ho, Yi-Tung Tsai, Dongsheng Wen, Lu Huang, Dan-Ning Zheng, Ya Gao, Yifan Zhang, Li Yu   +10 more
semanticscholar   +1 more source

Pharmacodynamic study of chitosan in combination with salvianolic acid B in the treatment of CC14‐induced liver fibrosis in mice

Clinical and Experimental Pharmacology and Physiology, 2023
Liver fibrosis is a chronic liver lesion caused by excessive deposition of the extracellular matrix after liver damage, resulting in fibrous scarring of liver tissue.
Z. Yao, Minshu Du, Yalu Wang, He Zhu, L. Shu, X. You, Jing Wang   +6 more
semanticscholar   +1 more source

ROS responsive conductive microspheres loaded with salvianolic acid B as adipose derived stem cell carriers for acute myocardial infarction treatment.

Biomaterials
Stem cell therapy is currently the most promising strategy for the treatment of myocardial infarction. However, the development of injectable cell carriers that can scavenge reactive oxygen species (ROS) in the infarct zone to improve transplanted cell ...
Lei Mu, Ruonan Dong, Congye Li, Jiangwei Chen, Ying Huang, Tongyang Li, Baolin Guo   +6 more
semanticscholar   +1 more source

An injectable peptide hydrogel with excellent self-healing ability to continuously release salvianolic acid B for myocardial infarction.

Biomaterials, 2021
Drug-loaded hydrogels can improve blood supply and inhibit extracellular matrix degradation after myocardial infarction. However, due to the continual dynamic motion of cardiac tissue, the hydrogel structure cannot be reconstructed in time, causing ...
Rui Chen, Chenqi Zhu, Liu Xu, Yi-huang Gu, Shujing Ren, H. Bai, Qin Zhou, Xin Liu, Sheng-feng Lu, Xiao-lin Bi, Weidong Li, X. Jia, Zhipeng Chen   +12 more
semanticscholar   +1 more source

Exploring the anti-amyloid potential of salvianolic acid A against the ALS-associated mutant SOD1: insights from molecular docking and molecular dynamic simulations

Molecular Simulation
A central feature of a variety of related neurological disorders, including amyotrophic lateral sclerosis (ALS), is the deposition of misfolded protein aggregates in key regions of the human brain.
Zainab Abdullah Waheed, B. Seyedalipour, Abasalt Hosseinzadeh Colagar, Payam Baziyar   +3 more
semanticscholar   +1 more source

Protective effects of Salvianolic acid B on rat ferroptosis in myocardial infarction through upregulating the Nrf2 signaling pathway.

International Immunopharmacology, 2022
Accumulating evidence has highlighted the role of ferroptosis, a novel type of programmed cell death involved in the pathological process of myocardial infarction (MI).
Yue-e Shen, Xinyu Shen, Shulin Wang, Yunyun Zhang, Yue Wang, Ye-Lei Ding, Jia-Ying Shen, J. Zhao, H. Qin, Yijiao Xu, Qian Zhou, Xindong Wang, Jian-ping Shen   +12 more
semanticscholar   +1 more source

Pharmacological manipulation of Ezh2 with Salvianolic acid B results in tumor vascular normalization and synergizes with cisplatin and T cell-mediated immunotherapy.

Pharmacological Research, 2022
Tumor vasculature is characterized by aberrant structure and function, resulting in immune suppressive profiles of tumor microenvironment (TME) through limiting immune cell infiltration into tumors. The defective vascular perfusion in tumors also impairs
C. Qian, Chunmei Yang, Yu Tang, Weiwei Zheng, Yueke Zhou, Shan Zhang, Mengyao Song, Peng Cheng, Zhonghong Wei, Chongjin Zhong, Li Wan, Aiyun Wang, Yang Zhao, Yin Lu   +13 more
semanticscholar   +1 more source

Research progress of salvianolic acid A

China Journal of Chinese Materia Medica, 2011
Salvianolic acid A is a water-soluble component from Danshen, which is frequently used in traditional Chinese medicine. High performance liquid chromatography was often used to analyze content of salvianolic acid A. The yield of salvianolic acid A increased by the technological improvement of extraction and separation.
openaire   +1 more source

Synthesis of (+)-salvianolic acid A from sodium Danshensu

Tetrahedron, 2018
Abstract (+)-Salvianolic acid A, one of the most active components in the traditional Chinese medicine Danshen, has been synthesized over 10 steps in 6.5% overall yield. Starting from inexpensive ortho-vanillin and sodium Danshensu (synthesized via asymmetric catalysis in our group), the process consists of the following: A Wittig reaction that gives
Kai Xu, Hao Liu, Delong Liu, Cheng Sheng, Jiefeng Shen, Wanbin Zhang   +5 more
openaire   +1 more source

The asymmetric total synthesis of (+)-salvianolic acid A

Tetrahedron, 2016
Abstract An asymmetric synthesis of (+)-salvianolic acid A with cardioprotective properties, has been accomplished in a convergent manner in eight steps and 10.6% overall yield. This synthesis features an asymmetric addition of organometallics to optically pure 2,3-epoxypropionate in the presence of BF3·Et2O, Ru(III)-catalyzed directed C H ...
Yong Zheng, Wei-Bin Song, Li-Jiang Xuan
openaire   +1 more source