Results 191 to 200 of about 667,703 (231)

Tree thorns-inspired hyaluronic acid-based dissolving microneedles loaded with salvianolic acid B for effective hypertrophic scar treatment with enhanced long-term stability.

Carbohydrate Polymers
Hypertrophic scar (HS) represents a natural consequence of abnormal fibroproliferation occurring during wound healing, which not only leads to tissue dysfunction but also causes psychological issues for patients.
Bricard Mbituyimana, Longjun Luo, Fuyu Qi, Yuchi Jiang, O. Atta, M. Kishta, Mostafa Maboruk, Min Wu, Wei Ge, Zhijun Shi, Guang Yang   +10 more
semanticscholar   +1 more source

Salvianolic acid B protects against pulmonary fibrosis by attenuating stimulating protein 1‐mediated macrophage and alveolar type 2 cell senescence

Phytotherapy Research, 2023
Idiopathic pulmonary fibrosis (IPF), as the most common idiopathic interstitial pneumonia, is caused by a complex interaction of pathological mechanisms.
Yijie Li, Ranyun Chen, Jian-zhi Wu, Xiaoyong Xue, Tiegang Liu, Guiying Peng, Ruiyu Wu, Lei Wang, Kexin Jia, Ya-jie Cai, Xiaojiaoyang Li   +10 more
semanticscholar   +1 more source

Quaternized chitosan/Salvianolic acid B multifunctional hydrogel with ROS/glucose dual responsive properties for diabetic wound healing.

Carbohydrate Polymers
Diabetic wounds (DW) represent one of the most severe and persistent complications of diabetes, whose healing process is hindered by excessive accumulation of reactive oxygen species (ROS), dysregulated inflammation, and abnormal macrophage polarization.
Yanping Li, Xin Wang, Chenjiao Miao, Miao Song, Zheng Cao   +4 more
semanticscholar   +1 more source

Salvianolic acid B inhibits hepatic stellate cell activation and liver fibrosis by targeting PDGFRβ.

International Immunopharmacology, 2023
Liver fibrosis is a reversible pathological process and a wound healing response to liver injury. As an early stage of various liver diseases, liver fibrosis can develop into cirrhosis, liver failure, and even liver cancer if not controlled in time ...
Fangbin Liu, Shengnan Li, Panpan Chen, Yanqiu Gu, Shaozhan Wang, Lei Wang, Chun Chen, Rong Wang, Yongfang Yuan   +8 more
semanticscholar   +1 more source

Salvianolic Acid B Attenuates Hypertrophic Scar Formation In Vivo and In Vitro

Aesthetic Plastic Surgery, 2023
Hypertrophic scars (HTSs) are a fibroproliferative disorder that occur following skin injuries. Salvianolic acid B (Sal-B) is an extractant from Salvia miltiorrhiza that has been reported to ameliorate fibrosis in multiple organs. However, the antifibrotic effect on HTSs remains unclear. This study aimed to determine the antifibrotic effect of Sal-B in
Chio-Hou, Chong, Jia-Ming, Sun, Yu-Xin, Liu, Yi-Tung, Tsai, Dan-Ning, Zheng, Yi-Fan, Zhang, Li, Yu   +6 more
openaire   +2 more sources

The use of PEGylated liposomes to prolong the circulation lifetime of salvianolic acid B

Fìtoterapìâ, 2012
The clinical application of salvianolic acid B (Sal B), a potential therapeutic agent for cardiovascular diseases isolated from Salvia miltiorrhiza, is greatly restricted by its short half-life and low bioavailability. To improve therapeutic effects and prolong the systemic circulation time of Sal B, liposomes, composed of soybean phosphatidylcholine ...
Limei Han, Xun Sun, Dongyan Gao
exaly   +3 more sources

Rapid and simultaneous determination of salvianolic acid A and salvianolic acid B by complex chromatography and study on related mechanism of coordination

Analytica Chimica Acta, 2008
Abstract Salvianolic acid A (Sal A) and salvianolic acid B (Sal B) are water-soluble phenolic acids in Danshen extract and they have high medicinal value. A rapid and novel complex high-performance liquid chromatography (HPLC) method has been developed and validated for the simultaneous determination of Sal A and Sal B within 10 min.
Beibei Zhou, Jian Pan, Jia Wang
openaire   +1 more source

Salvianolic acid B protects against UVB-induced skin aging via activation of NRF2.

Phytomedicine
BACKGROUND Prolonged exposure to sun radiation may result in harmful skin photoaging. Therefore, discovering novel anti-photoaging treatment modalities is critical.
Jia-Ming Sun, Yuxin Liu, Yang-Dan Liu, Chiakang Ho, Yi-Tung Tsai, Dongsheng Wen, Lu Huang, Danning Zheng, Ya Gao, Yifan Zhang, Li Yu   +10 more
semanticscholar   +1 more source

Protective effects of Salvianolic acid B on rat ferroptosis in myocardial infarction through upregulating the Nrf2 signaling pathway.

International Immunopharmacology, 2022
Accumulating evidence has highlighted the role of ferroptosis, a novel type of programmed cell death involved in the pathological process of myocardial infarction (MI).
Yue-e Shen, Xinyu Shen, Shulin Wang, Yunyun Zhang, Yue Wang, Ye Ding, Jia-Ying Shen, J. Zhao, H. Qin, Yijiao Xu, Qian Zhou, Xindong Wang, Jian-ping Shen   +12 more
semanticscholar   +1 more source

[Protective mechanism of salvianolic acid B on blood vessels].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023
Salvianolic acid B(Sal B) is the main water-soluble component of Salvia miltiorrhiza Bunge. Studies have found that Sal B has a good protective effect on blood vessels. Sal B can protect endothelial cells by anti-oxidative stress, inducing autophagy, inhibiting endoplasmic reticulum stress(ERS), inhibiting endothelial inflammation and adhesion molecule
Chun-Kun, Yang, Qing-Quan, Pan, Zhuang, Tian, Yan-Jun, DU, Feng-Qin, Sun, Jin, Lu, Jun, Li   +6 more
openaire   +1 more source