Results 201 to 210 of about 667,703 (231)

Salvianolic acid B alleviated myocardial ischemia-reperfusion injury via modulating SIRT3-mediated crosstalk between mitochondrial ROS and NLRP3.

Phytomedicine
BACKGROUND Mitochondrial ROS (mtROS) accumulation and NLRP3 inflammasome activation are critical in the pathogenesis of myocardial ischemia-reperfusion injury (MIRI).
Xiaohong Wei, Jie Chen, Xuefen Wu, Qian Zhang, Gui-Yang Xia, Xinyu Chu, Huan Xia, Sheng Lin, Hongcai Shang   +8 more
semanticscholar   +1 more source

Mechanism of action of Salvianolic Acid B by module-based network analysis

Bio-Medical Materials and Engineering, 2014
Salvianolic Acid B (Sal B) is one of the main medicinal ingredients of Radix Salvia miltiorrhiza (Danshen) and possesses a variety of pharmacological effects. The purpose of this study was to discover the new mechanism of action of Sal B based on the protein interaction network (PIN) analysis.
Zhenzhen, Ren, Xing, Wang, Shifeng, Wang, Chenxi, Zhai, Yusu, He, Yanling, Zhang, Yanjiang, Qiao   +6 more
openaire   +2 more sources

Immunomodulatory effects of Salvianolic acid B in a spontaneous abortion mouse model

Journal of Reproductive Immunology, 2020
Pregnancy is a kind of natural immune tolerance. Immune factors play an important role in recurrent spontaneous abortion and repeated implantation failure. Salvianolic acid B (SalB) has anti-tumor, anti-inflammatory, anti-oxidation and immunomodulatory functions.
Jing, Wang, Chi, Liu, Weitao, Que, Masayuki, Fujino, Guoqing, Tong, Hua, Yan, Xiao-Kang, Li   +6 more
openaire   +2 more sources

Pharmacological manipulation of Ezh2 with Salvianolic acid B results in tumor vascular normalization and synergizes with cisplatin and T cell-mediated immunotherapy.

Pharmacological Research, 2022
Tumor vasculature is characterized by aberrant structure and function, resulting in immune suppressive profiles of tumor microenvironment (TME) through limiting immune cell infiltration into tumors. The defective vascular perfusion in tumors also impairs
C. Qian, Chunmei Yang, Yu Tang, Weiwei Zheng, Yueke Zhou, Shan Zhang, Mengyao Song, Peng Cheng, Zhonghong Wei, Chongjin Zhong, Li Wan, Aiyun Wang, Yang Zhao, Yin Lu   +13 more
semanticscholar   +1 more source

ROS responsive conductive microspheres loaded with salvianolic acid B as adipose derived stem cell carriers for acute myocardial infarction treatment.

Biomaterials
Stem cell therapy is currently the most promising strategy for the treatment of myocardial infarction. However, the development of injectable cell carriers that can scavenge reactive oxygen species (ROS) in the infarct zone to improve transplanted cell ...
Lei Mu, Ruonan Dong, Congye Li, Jiangwei Chen, Ying Huang, Tongyang Li, Baolin Guo   +6 more
semanticscholar   +1 more source

Salvianolic acid B ameliorates CNS autoimmunity by suppressing Th1 responses

Neuroscience Letters, 2016
Experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), is a Th1 and Th17 cell-mediated CNS autoimmune disease. Therefore, immune regulation is a key target for therapy. Salvianolic acid B (Sal B) is a major water-soluble bioactive component of the famous traditional Chinese medicine Salvia miltiorrhiza, which is ...
Zhihui, Dong, Dihui, Ma, Ye, Gong, Tingmin, Yu, Gang, Yao   +4 more
openaire   +2 more sources

Phospholipids of inhaled liposomes determine the in vivo fate and therapeutic effects of salvianolic acid B on idiopathic pulmonary fibrosis.

Journal of Controlled Release
Since phospholipids have an important effect on the size, surface potential and hardness of liposomes that decide their in vivo fate after inhalation, this research has systematically evaluated the effect of phospholipids on pulmonary drug delivery by ...
Jianqing Peng, Qin Wang, Runbin Sun, Ke Zhang, Yi Chen, Zipeng Gong   +5 more
semanticscholar   +1 more source

Effects of ultrasonic processing on degradation of salvianolic acid B in aqueous solution

Journal of Pharmaceutical and Biomedical Analysis, 2016
To evaluate the stability of salvianolic acid B (Sal B) under ultrasound-assisted extraction in the pharmaceutical industry, degradation of Sal B under ultrasonic irradiation was investigated as the function of buffer concentration, pH, and temperature.
Y X, Guo, L, Zhang, L, Lu, E H, Liu, C Z, Shi   +4 more
openaire   +2 more sources

Salvianolic acid B improves mitochondrial dysfunction of septic cardiomyopathy via enhancing ATF5-mediated mitochondrial unfolded protein response.

Toxicology and Applied Pharmacology
AIMS Septic cardiomyopathy is characterized by impaired contractile function and mitochondrial activity dysregulation. Salvianolic acid B (Sal B) is a potent therapeutic compound derived from the traditional Chinese medicine Salvia miltiorrhiza.
Renshan Chen, Anran Zheng, Yunjing Wang, Liyou Guo, Huaqian Dou, Liangyan Lu, Muhammad Rafiq, Peihua Li, Xiuhui Chen, Qing Xiao   +9 more
semanticscholar   +1 more source

Salvianolic acid B alleviates autoimmunity in Treg‐deficient mice via inhibiting IL2‐STAT5 signaling

Phytotherapy Research
Regulatory T cell (Treg) deficiency leads to immune dysregulation, polyendocrinopathy, enteropathy, and X‐linked (IPEX) syndrome, which is a CD4+ T cell‐driven autoimmune disease in both humans and mice.
Ting Wang, Jing Wang, Huan Xu, Han Yan, Ying Liu, Ning Zhang, Yawen Zhang, Jingmin Zhang, Jingxuan Xu, Lei Zhang, Xiaolu Ge, Mingjing Meng, Pei‐Qi Liu, Qiaozhi Yang, Daogang Qin, Sen Li, Baokun He   +16 more
semanticscholar   +1 more source