Results 41 to 50 of about 4,502,013 (256)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

DS-SIAUG: A Self-Training Approach Using a Disrupted Student Model for Enhanced Side-Scan Sonar Image Augmentation

Sensors
Side-scan sonar is a principal technique for subsea target detection, where the quantity of sonar images of seabed targets significantly influences the accuracy of intelligent target recognition.
Chengyang Peng, Shaohua Jin, Gang Bian, Yang Cui   +3 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

SelectAugment: Hierarchical Deterministic Sample Selection for Data Augmentation

, 2023
Data augmentation (DA) has been extensively studied to facilitate model optimization in many tasks. Prior DA works focus on designing augmentation operations themselves, while leaving selecting suitable samples for augmentation out of consideration. This
Chen, Zhibo, Lin, Shiqi, Zhang, Zhizheng, Li, Xin   +3 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Physics-Constrained PROSAIL-cGAN Approach for Spectral Sample Augmentation and LAI Inversion of Winter Wheat

智慧农业
ObjectiveThe leaf area index (LAI) is a key biophysical parameter that reflects the canopy structure and photosynthetic capacity of crops. However, the inversion of winter wheat LAI from remote sensing data is often constrained by the limited ...
LU Yihang, DONG Wen, ZHANG Xin, YAN Ruoyi, ZHANG Yujia, TANG Tao   +5 more
doaj   +1 more source

Data Augmentation and Spectral Structure Features for Limited Samples Hyperspectral Classification

Remote Sensing, 2021
For both traditional classification and current popular deep learning methods, the limited sample classification problem is very challenging, and the lack of samples is an important factor affecting the classification performance.
Wenning Wang, Xuebin Liu, Xuanqin Mou
doaj   +1 more source

fusion-jena/data-augmentation-ner-legal v1.0.0

, 2022
Source Code for Evaluating Data Augmentation for Named Entity Recognition over the German Legal ...
Erd, Robin, Feddoul, Leila
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Steady-State Security Region Boundary Characterization in Power Systems With Limited Samples: A Geometry-Guided Hybrid Approach

IEEE Access
In the context of the low-carbon transition of energy systems, power system operating conditions exhibit strong stochasticity, making rapid and accurate characterization of the steady-state security region boundary essential for online security ...
Hongyin Liu, Junzhao Cheng, Ruizhu Guo, Lan Yan, Yansong Cui, Jing Zi, Weiguang Hu   +6 more
doaj   +1 more source