Results 61 to 70 of about 116,076 (264)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Fault State Identification Method with Noise Robustness of Dry Gas Seals Based on Sample-Augmented MA1D-ResNet

Sensors
Dry gas seals are widely used in the petrochemical industry for shaft end sealing of compressors, pumps and other equipment involving flammable, explosive, toxic and harmful media.
Jinlin Chen, Jiahao Li, Xuexing Ding, Wei Xu, Pengju Li, Zhihao Xia   +5 more
doaj   +1 more source

RandMSAugment: A Mixed-Sample Augmentation for Limited-Data Scenarios

CoRR, 2023
The high costs of annotating large datasets suggests a need for effectively training CNNs with limited data, and data augmentation is a promising direction. We study foundational augmentation techniques, including Mixed Sample Data Augmentations (MSDAs) and a no-parameter variant of RandAugment termed Preset-RandAugment, in the fully supervised ...
Swarna Kamlam Ravindran, Carlo Tomasi
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

DS-SIAUG: A Self-Training Approach Using a Disrupted Student Model for Enhanced Side-Scan Sonar Image Augmentation

Sensors
Side-scan sonar is a principal technique for subsea target detection, where the quantity of sonar images of seabed targets significantly influences the accuracy of intelligent target recognition.
Chengyang Peng, Shaohua Jin, Gang Bian, Yang Cui   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Augmented SOLOW Model And The OECD Sample

International Business & Economics Research Journal (IBER), 2011
In their influential work on the augmented Solow model, Mankiw, Romer and Weil (1992) showed that cross-section evidence was reasonably consistent with the Solow growth model augmented to include human capital for a wide range of countries. However, for the sample of OECD countries, they found that the model had low explanatory power and underestimated
Giorgio Canarella, Stephen K. Pollard
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Physics-Constrained PROSAIL-cGAN Approach for Spectral Sample Augmentation and LAI Inversion of Winter Wheat

智慧农业
ObjectiveThe leaf area index (LAI) is a key biophysical parameter that reflects the canopy structure and photosynthetic capacity of crops. However, the inversion of winter wheat LAI from remote sensing data is often constrained by the limited ...
LU Yihang, DONG Wen, ZHANG Xin, YAN Ruoyi, ZHANG Yujia, TANG Tao   +5 more
doaj   +1 more source

Extended Subspace Projection Upon Sample Augmentation Based on Global Spatial and Local Spectral Similarity for Hyperspectral Imagery Classification

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2021
Band redundancy and limitation of labeled samples restrict the development of hyperspectral image classification (HSIC) greatly. To address the earlier issues, the classification models such as subspace-based support vector machines, which have gained a ...
Jiaochan Hu, Xueji Shen, Haoyang Yu, Xiaodi Shang, Qiandong Guo, Bing Zhang   +5 more
doaj   +1 more source