Results 81 to 90 of about 947,067 (264)

A Two-Stage Stochastic Optimization Model for Cruise Ship Food Provisioning with Substitution

Mathematics
The global cruise industry has demonstrated remarkable growth, with modern ships functioning as large-scale floating resorts. Effective food provisioning is a critical operational function that directly impacts both cost efficiency and passenger ...
Weilin Sun, Ying Yang, Shuaian Wang
doaj   +1 more source

Limitations of the incidence density ratio as approximation of the hazard ratio

Trials, 2019
Background Incidence density ratios (IDRs) are frequently used to account for varying follow-up times when comparing the risks of adverse events in two treatment groups.
Ralf Bender, Lars Beckmann
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Convergence Analysis of the Approximation Problems for Solving Stochastic Vector Variational Inequality Problems

Complexity, 2020
In this paper, we consider stochastic vector variational inequality problems (SVVIPs). Because of the existence of stochastic variable, the SVVIP may have no solutions generally.
Meiju Luo, Kun Zhang
doaj   +1 more source

Sample average approximation with heavier tails II: localization in stochastic convex optimization and persistence results for the Lasso

, 2018
We present exponential finite-sample nonasymptotic deviation inequalities for the SAA estimator's near-optimal solution set over the class of stochastic optimization problems with heavy-tailed random \emph{convex} functions in the objective and ...
Oliveira, Roberto I., Thompson, Philip
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A Novel Stochastic Framework for Integrated Airline Operation Planning: Addressing Codeshare Agreements, Overbooking, and Station Purity

Aerospace
This study presents an integrated optimization framework for fleet assignment, flight scheduling, and aircraft routing under uncertainty, addressing a core challenge in airline operational planning.
Kübra Kızıloğlu, Ümit Sami Sakallı
doaj   +1 more source

Identifying Effective Scenarios for Sample Average Approximation

, 2019
We introduce a method to improve the tractability of the well-known Sample Average Approximation (SAA) without compromising important theoretical properties, such as convergence in probability and the consistency of an independent and identically distributed (iid) sample.
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source