Results 91 to 100 of about 22,781,464 (398)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Magnetostriction strain measurement: heterodyne laser interferometry versus strain gauge technique [PDF]
, 2013 Deformation of the ferromagnetic material, known as magnetostriction, causes vibrations and noise of electrical machines and transformer cores. A setup by using heterodyne laser interferometers has been built to measure the magnetostriction strains as a
Gorji Ghalamestani, Setareh +3 more
core
, 2008 We perform broadband phase sensitive measurements of the reflection coefficient from 45 MHz up to 20 GHz employing a vector network analyzer with a 2.4 mm coaxial sensor which is terminated by the sample under test.
Elvira Ritz +5 more
core +1 more source
Bio-Protocol, 2016 Variation in the tissue structure of short rotation coppice (SRC) willow is a principle factor driving differences in lignocellulosic sugar yield yet much of the physiology and development of this tissue is unknown.
Nicholas Brereton
doaj +1 more source
The generation and use of recombinant extracellular vesicles as biological reference material
Nature Communications, 2019 Recent years have seen an increase of extracellular vesicle (EV) research geared towards biological understanding, diagnostics and therapy. However, EV data interpretation remains challenging owing to complexity of biofluids and technical variation ...
E. Geeurickx +26 more
semanticscholar +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Revista Mexicana de Ciencias Geológicas, 2018 An objective procedure involving fourteen statistical tests (a total of thirty-four variants) for detection and rejection of outliers in a univariate sample was applied to five geochemical Reference Material (RM) databases of intrusive rocks from the ...
Mirna Guevara +2 more
doaj
Bio-damages of materials and of material samples.
Тонкие химические технологии, 2007 In the review was shown the development of the theoretical performances bio-damages of materials in the exploitation conditions and were developed the recommendation of the protection of material samples.
S. A. Semenov +3 more
openaire +1 more source