Basic principles of sample size calculation
The calculation of sample size helps a medical researcher to assess cost, time, and feasibility of his project besides scientific justification and validity. Although frequently reported in journals, the details or the elements of sample size calculation
Shivam Pandey
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Approaches to sample size calculation for clinical trials in rare diseases [PDF]
We discuss 3 alternative approaches to sample size calculation: traditional sample size calculation based on power to show a statistically significant effect, sample size calculation based on assurance, and sample size based on a decision-theoretic ...
Day, Simon +8 more
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Basics of statistics-3: Sample size calculation – (i)
Introduction: From a practicing oncologist's perspective, sample size calculation is a very intriguing aspect of medical statistics. Methods: Basic aspects of sample size calculation in relevant case scenarios are discussed.
H S Darling
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Sample size calculation for a stepped wedge trial. [PDF]
BACKGROUND: Stepped wedge trials (SWTs) can be considered as a variant of a clustered randomised trial, although in many ways they embed additional complications from the point of view of statistical design and analysis.
Ambler, Gareth +5 more
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When designing any research project, definition is required of the sample size needed in order to carry out the study. This sample size is an estimate of the number of patients required in accordance with the pursued study objective. In this context, it is more efficient in terms of both cost and time to use samples than to work with the entire ...
Mm, Rodríguez Del Águila +1 more
openaire +2 more sources
Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study [PDF]
Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factors ...
Boswood, A +4 more
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Comparison of the determination of a low-concentration active ingredient in pharmaceutical tablets by backscatter and transmission raman spectrometry [PDF]
A total of 383 tablets of a pharmaceutical product were analyzed by backscatter and transmission Raman spectrometry to determine the concentration of an active pharmaceutical ingredient (API), chlorpheniramine maleate, at the 2% m/m (4 mg) level.
Andrews, John +5 more
core +1 more source
Sample Size calculation based on research Approaches in Animal Studies
Background: Sample sizes that are too small can produce inconclusive results, while sample sizes that are too large may raise ethical concerns and produce trivial outcomes.
Alireza Pakgohar
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The peroxidation of leukocytes index ratio reveals the prooxidant effect of green tea extract [PDF]
Despite tea increased plasma nonenzymatic antioxidant capacity, the European Food Safety Administration (EFSA) denied claims related to tea and its protection from oxidative damage.
Longhitano, Yaroslava +6 more
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Sample Size and Statistical Power Calculation in Genetic Association Studies [PDF]
A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases.
Eun Pyo Hong, Ji Wan Park
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