Results 251 to 260 of about 2,022,785 (307)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Seroprevalence and associated risk factors for feline panleukopenia virus infection among managed giant pandas in China. [PDF]

Vet Res
Li Y, Jia R, Zhang H, Chen X, Zeng J, Lan J, Yue C, Zhang D, Huang W, Yang W, Fan X, Xia X, Hou R, Feng N, Liu S.   +14 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Investigating the differences in <i>Salmonella</i> serovar transmission within broiler production. [PDF]

Front Vet Sci
Ayala Velastegui D, Shariat NW.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Temporal Feasibility Constraints on Wingbeat-Call Synchrony in Actively Echolocating Bats. [PDF]

Ecol Evol
Umadi R.
europepmc   +1 more source

Tetranychus evansi (Tetranychidae) spider mites now a major solanaceous crop pest in Côte d'Ivoire. [PDF]

Exp Appl Acarol
Deletre E, Latapie C, Migeon A, Auger P, Larpin N, Laboisse S, Martin T.   +6 more
europepmc   +1 more source

Megalurothrips usitatus and other Thrips (Thysanoptera: Thripidae) Associated with Lablab purpureus (Fabales: Fabaceae) in South Florida. [PDF]

J Insect Sci
Ivey CB, Hahn PG, Vallad G, Soto-Adames F, Hochmuth R, Beuzelin J, Jean-Louis A, Smith HA.   +7 more
europepmc   +1 more source

<i>Leptospira</i> Species Infection and Seropositivity in Domestic Livestock and Feral Swine in Puerto Rico. [PDF]

Transbound Emerg Dis
Dirsmith KL, Nally JE, Sutherland G, Hamond C, Galloway RL, LeCount K, Anderson T, Soltero FV, Rivera-García S, Novak V, Olivieri-Cintrón GE, Gruver K, Brown VR, Glassey C, McKinley AS, Candelaria O, Stephens L, Schafer IJ.   +17 more
europepmc   +1 more source