Results 91 to 100 of about 3,977,371 (295)

Quality sampling using coiled tubing drilling in deep mineral exploration

open access: yes, 2012
The sampling time, the costs and its quality are the three factors that determine the best method of drilling in mineral exploration. The two principal methods of reverse circulation (RC) and diamond core drilling are often used in combination by mine ...
Rasouli, Vamegh   +2 more
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Exact methods for comparison of estimation strategies in survey sampling. [PDF]

open access: yes, 2010
PhDMany strategies in survey sampling depend on large sample approximation formulae for design-based inference on finite population parameters, which are not valid for small samples. We develop an approach using matrix algebra to tackle many problems
Khan, Kaleem Uddin
core   +4 more sources

Interfailure Data with Constant Hazard Function in the Presence of Change-Points

open access: yesRevstat Statistical Journal, 2007
Markov Chain Monte Carlo (MCMC) methods are used to perform a Bayesian analysis for interfailure data with constant hazard function in the presence of one or more change-points.
Jorge Alberto Achcar   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Parallel hierarchical sampling:a general-purpose class of multiple-chains MCMC algorithms [PDF]

open access: yes
This paper introduces the Parallel Hierarchical Sampler (PHS), a class of Markov chain Monte Carlo algorithms using several interacting chains having the same target distribution but different mixing properties.
Antonietta Mira, Fabio Rigat
core  

Lightweight Cryptanalysis of IoT Encryption Algorithms: Is Quota Sampling the Answer?

open access: yesIEEE Access
Rapid growth in the number of small sensor devices known as the Internet of Things (IoT) has seen the development of lightweight encryption algorithms. Two well-known lightweight algorithms are SIMON and SIMECK which have been specifically designed for ...
Jonathan Cook   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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