Results 41 to 50 of about 7,676,917 (278)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Deep learning‐based identification of sinoatrial node‐like pacemaker cells from SHOX2/HCN4 double‐positive cells differentiated from human iPS cells

open access: yesJournal of Arrhythmia, 2023
Background Cardiomyocytes derived from human iPS cells (hiPSCs) include cells showing SAN‐ and non‐SAN‐type spontaneous APs. Objectives To examine whether the deep learning technology could identify hiPSC‐derived SAN‐like cells showing SAN‐type‐APs by ...
Takayuki Wakimizu   +6 more
doaj   +1 more source

Greer, Douglas [PDF]

open access: yes, 2020
Cornell University, 1968 PhD Cornell University, 1967 MA University of Oregon, 1965 MA University of Oregon, 1963 BShttps://scholarworks.sjsu.edu/erfa_bios/1303/thumbnail ...
San Jose State University
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Reseña de "El elogio a los Libertadores. Presencia de José de San Martín y Simón Bolívar en la Universidad de San Marcos de Lima", de Ricardo Pinto-Bazurco Mendoza (compilación y prólogo)

open access: yesRiqch'ariy, 2021
Entre la cantidad de publicaciones enfocadas en la temática del bicentenario de la independencia y nacimiento de la república peruana, se presentan también algunas que transcriben documentos de tan interesante coyuntura.
Roberto Ojeda Escalante
doaj  

Fat extraction from mechanically deboned beef with various pH and alkalis : a thesis presented in fulfilment of the requirements for the degree of Master of Technology at Massey University [PDF]

open access: yes, 1994
The study showed that meat surimi with a 1.3% fat content could be prepared from mechanically deboned beef. The process used in the laboratory to prepare the meat surimi was a relatively simple process requiring few unit operations, unit ...
Wu, San-Der
core  

Douglass, Malcolm Paul [PDF]

open access: yes, 2020
University of California, Los Angeles, English, Ph.D. 1981 Claremont Graduate University, Education, MA 1976 Amherst College, English, BA 1974https://scholarworks.sjsu.edu/erfa_bios/1288/thumbnail ...
San Jose State University
core   +1 more source

Adsorption of proteins to thin-films of PDMS and its effect on the adhesion of human endothelial cells [PDF]

open access: yes, 2011
This paper describes a simple and inexpensive procedure to produce thin-films of poly(dimethylsiloxane). Such films were characterized by a variety of techniques (ellipsometry, nuclear magnetic resonance, atomic force microscopy, and goniometry) and ...
Bizios, Rena   +7 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Propuestas y estrategias para la protección y promoción del desarrollo de drogas huérfanas

open access: yesRevista Iberoamericana de la Propiedad Intelectual
El objeto de este trabajo es brindar propuestas y estrategias para incentivar el desarrollo de este tipo de medicamentos. Las propuestas consisten en la integración entre la exclusividad regulatoria y la protección por patentes, dado que los diversos ...
Angela Santorsa Gutierrez
doaj   +1 more source

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