Results 41 to 50 of about 7,951,181 (327)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
La identificación de los jóvenes de Argentina y España con los personajes de ficción
Austral Comunicación, 2014 A raíz de las escasas investigaciones con carácter empírico realizadas sobre la identificación de jóvenes con los personajes de la ficción y del entretenimiento mediático, este estudio descubre que esa identificación es una variable explicativa para ...
Sebastián Sánchez Castillo +1 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Journal of Arrhythmia, 2023 Background Cardiomyocytes derived from human iPS cells (hiPSCs) include cells showing SAN‐ and non‐SAN‐type spontaneous APs. Objectives To examine whether the deep learning technology could identify hiPSC‐derived SAN‐like cells showing SAN‐type‐APs by ...
Takayuki Wakimizu +6 more
doaj +1 more source
Spinal Accessory Nerve Duplication – A Rare Anatomical Consternation During Neck Dissectio
Asian Pacific Journal of Cancer Care, 2021 Prevention of the spinal accessory nerve (SAN) is an indispensable aspect of the functional neck dissection surgery to avoid highly disabling shoulder syndrome postoperatively.
Rohit Jindal +6 more
doaj +1 more source
Fat extraction from mechanically deboned beef with various pH and alkalis : a thesis presented in fulfilment of the requirements for the degree of Master of Technology at Massey University [PDF]
, 1994 The study showed that meat surimi with a 1.3% fat content could be prepared from mechanically deboned beef. The process used in the laboratory to prepare the meat surimi was a relatively simple process requiring few unit operations, unit ...
Wu, San-Der
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Riqch'ariy, 2021 Entre la cantidad de publicaciones enfocadas en la temática del bicentenario de la independencia y nacimiento de la república peruana, se presentan también algunas que transcriben documentos de tan interesante coyuntura.
Roberto Ojeda Escalante
doaj
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source