Results 51 to 60 of about 2,279,602 (264)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2018 Magíster en Educación en Ciencias de la SaludIntroducción: La simulación clínica con paciente estandarizado es una metodología utilizada en la actualidad durante el proceso de enseñanza-aprendizaje, provee un ambiente seguro donde el estudiante tiene la ...
San Juan Cortés, Hugo +1 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Unidentified man wearing San Antonio Rifles uniform
, 1889 Photograph shows waist-length studio portrait of an unidentified man in uniform.Photographer's imprint: '' Callaway / San Antonio'
Callaway (San Antonio, Tex.)
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Synthesis and properties of novel styrene acrylonitrile/polypropylene blends with enhanced toughness
Chemistry Central Journal, 2018 Background Although polypropylene (PP) has been widely used, its brittleness restricts even further applications. Methods In this study, we have used a melt blending process to synthesize styrene acrylonitrile (SAN)/PP blends containing 0, 5, 10, 15 and ...
Yi-jun Liao, Xiao-li Wu, Lin Zhu, Tao Yi
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Unidentified man in San Antonio Rifles uniform
, 1890 Photograph shows waist-length studio portrait of an unidentified man wearing the five-button blouse of the San Antonio Rifles ...
Callaway (San Antonio, Tex.)
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The “Decolonizing” of Knowledge: A New Perspective on the Cape’s Storytelling (Review)
Ученые записки Института Африки Российской академии наукReview of the book: Bam J. (2021). Ausi Told Me: Why Cape Herstoriographies Matter. Auckland Park: Jacana Media. 312 p.
Turianitsa Daria
doaj +1 more source
La identificación de los jóvenes de Argentina y España con los personajes de ficción
Austral Comunicación, 2014 A raíz de las escasas investigaciones con carácter empírico realizadas sobre la identificación de jóvenes con los personajes de la ficción y del entretenimiento mediático, este estudio descubre que esa identificación es una variable explicativa para ...
Sebastián Sánchez Castillo +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source