Results 61 to 70 of about 1,869,450 (267)

Application Development of High-speed EMUs Resistance Force Reduction and Weight Lightening

机车电传动, 2012
For decreasing the train operation resistance force, key technologies of high-speed EMUs aero-dynamical design and lightweight design were studied. By the systematic analysis and optimization of the major factors to influence train operation resistance ...
DING San-san
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

San Agustín de Hipona, San Fulgencio de Ruspe y el monacato en el África porconsular

Carthaginensia, 2018
El introductor del monacato en Italia es el obispo San Eusebio de Vercelli quien había sido uno de los oyentes de San Atanasio en Roma durante los años 339 - 342 cuando San Eusebio era un simple presbítero.
Gonzalo Fernández Hernández
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Computational assessment of the functional role of sinoatrial node exit pathways in the human heart.

PLoS ONE, 2017
AimThe human right atrium and sinoatrial node (SAN) anatomy is complex. Optical mapping experiments suggest that the SAN is functionally insulated from atrial tissue except at discrete SAN-atrial electrical junctions called SAN exit pathways, SEPs ...
Sanjay R Kharche, Edward Vigmond, Igor R Efimov, Halina Dobrzynski   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Di sản và vấn đề giáo dục di sản cho học sinh trung học phổ thông

Tạp chí Khoa học Đại học Cần Thơ, 2019
Nghiên cứu về di sản và giáo dục di sản trong trường phổ thông, trước hết cần nhận dạng được di sản với 3 nhóm gồm di sản thiên nhiên, di sản văn hóa và di sản hỗn hợp. Mỗi di sản được phân loại đều có tiêu chí rõ ràng, những di sản được UNESCO công nhận
Dương Quỳnh Phương, Đỗ Văn Hảo   +1 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Sans Occident/Occident Sans

Les Cahiers philosophiques de Strasbourg
Je rappelle ici l’une des plus constantes préoccupations de la pensée de Jean-Luc Nancy : celle du destin d’un Occident qui, au moment même où il paraît accomplir son élargissement au monde entier, est amené à faire, de plus en plus, le constat de son propre effacement, de son déclin, ou de sa finitude. Je le fais tout en déplaçant quelque peu le point
openaire   +1 more source