Results 41 to 50 of about 2,279,602 (264)

La cláusula penal abusiva y el requisito de la desproporción de la pena

Revista Jurídica Austral, 2020
Se analiza el requisito central del cual depende si una cláusula penal es o no abusiva (y, por ende, si debe o no ser reducida): su desproporción. A este efecto, debe dilucidarse si es proporcionada con el valor de la prestación o del resarcimiento que ...
Andrés Sánchez Herrero
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Víctimas del delito y justicia restaurativa

Revista Internacional de Derechos Humanos
El texto analiza la reparación del daño a las víctimas del delito como parte integrante de la justicia restaurativa. Aborda la teoría del garantismo penal de Luigi Ferrajoli con un enfoque victimológico, lo cual le permite revisar el sistema penal ...
María Fernanda Sanchez Díaz
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Tratamiento de la colusión en la contratación pública: una visión del caso colombiano

Revista de Derecho, 2014
La colusión, entendida como un pacto ilícito en daño a tercero, la cual se da en los procesos de contratación pública, es un acuerdo anticompetitivo sancionado por el numeral 9 del artículo 47 del Decreto 2153 de 1992, y más recientemente por la Ley 1474
Camilo Ernesto Ossa Bocanegra
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Rules for the government of public schools of San Antonio, Texas, as revised and adopted by the San Antonio School Board, August, 1913

, 1913
Course of study for the public schools of San Antonio, Texas, for the 1913-1914 school year. The books lists textbooks and other materials that should be used in the San Antonio public schools.
San Antonio Independent School District (Texas)
core  

Análisis de la gestión del riesgo de las empresas que se [desempeñan] en actividades de alta montaña, montaña y trekking en la comuna de San Pedro de Atacama [PDF]

, 2023
Ingeniería en Gestión de Expediciones y Ecoturismo, Licenciado en Ciencias de la IngenieríaEsta investigación se centró en evaluar la gestión del riesgo de los operadores turísticos de alta montaña, montaña y trekking registrados en el Servicio Nacional ...
Benjamín Ignacio, Astudillo Riveros, San Martín Magnere, Paloma, Mouat Parraguez, Alondra, Batarce Kirigin, Marcelo Lucas   +3 more
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