Results 71 to 80 of about 7,951,181 (327)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Application Development of High-speed EMUs Resistance Force Reduction and Weight Lightening

open access: yes机车电传动, 2012
For decreasing the train operation resistance force, key technologies of high-speed EMUs aero-dynamical design and lightweight design were studied. By the systematic analysis and optimization of the major factors to influence train operation resistance ...
DING San-san
doaj  

Synthesis and properties of novel styrene acrylonitrile/polypropylene blends with enhanced toughness

open access: yesChemistry Central Journal, 2018
Background Although polypropylene (PP) has been widely used, its brittleness restricts even further applications. Methods In this study, we have used a melt blending process to synthesize styrene acrylonitrile (SAN)/PP blends containing 0, 5, 10, 15 and ...
Yi-jun Liao, Xiao-li Wu, Lin Zhu, Tao Yi
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

San Agustín de Hipona, San Fulgencio de Ruspe y el monacato en el África porconsular

open access: yesCarthaginensia, 2018
El introductor del monacato en Italia es el obispo San Eusebio de Vercelli quien había sido uno de los oyentes de San Atanasio en Roma durante los años 339 - 342 cuando San Eusebio era un simple presbítero.
Gonzalo Fernández Hernández
doaj  

A Collaborative Kalman Filter for Time-Evolving Dyadic Processes [PDF]

open access: yes, 2015
We present the collaborative Kalman filter (CKF), a dynamic model for collaborative filtering and related factorization models. Using the matrix factorization approach to collaborative filtering, the CKF accounts for time evolution by modeling each low ...
Gultekin, San, Paisley, John
core  

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Innovate Magazine / Annual Review 2011-2012 [PDF]

open access: yes, 2012
This year\u27s issue highlights some of the ways the SJSU School of Library and Information Science is being a catalyst for global innovation, explores the tools SJSU SLIS master\u27s students and faculty use to interact in our innovative online learning
San Jose State University
core   +1 more source

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