Results 81 to 90 of about 7,951,181 (327)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Tbx5 overexpression in embryoid bodies increases TAK1 expression but does not enhance the differentiation of sinoatrial node cardiomyocytes

Biology Open, 2023
Yunkai Dai, Fatemeh Nasehi, Charles D. Winchester, Ann C. Foley   +3 more
doaj   +1 more source

Existencia y alcance de la obligación de renegociar la extinción unilateral del contrato

Revista Jurídica Austral
El tercer párrafo del artículo 1011 del Código Civil y Comercial de la Argentina impone a la parte que quiere rescindir un contrato de duración la obligación de renegociar el tema previamente.
Andrés Sánchez Herrero
doaj   +1 more source

Di sản và vấn đề giáo dục di sản cho học sinh trung học phổ thông

Tạp chí Khoa học Đại học Cần Thơ, 2019
Nghiên cứu về di sản và giáo dục di sản trong trường phổ thông, trước hết cần nhận dạng được di sản với 3 nhóm gồm di sản thiên nhiên, di sản văn hóa và di sản hỗn hợp. Mỗi di sản được phân loại đều có tiêu chí rõ ràng, những di sản được UNESCO công nhận
Dương Quỳnh Phương, Đỗ Văn Hảo   +1 more
doaj   +1 more source

Sans Occident/Occident Sans

Les Cahiers philosophiques de Strasbourg
Je rappelle ici l’une des plus constantes préoccupations de la pensée de Jean-Luc Nancy : celle du destin d’un Occident qui, au moment même où il paraît accomplir son élargissement au monde entier, est amené à faire, de plus en plus, le constat de son propre effacement, de son déclin, ou de sa finitude. Je le fais tout en déplaçant quelque peu le point
openaire   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Computational assessment of the functional role of sinoatrial node exit pathways in the human heart.

PLoS ONE, 2017
AimThe human right atrium and sinoatrial node (SAN) anatomy is complex. Optical mapping experiments suggest that the SAN is functionally insulated from atrial tissue except at discrete SAN-atrial electrical junctions called SAN exit pathways, SEPs ...
Sanjay R Kharche, Edward Vigmond, Igor R Efimov, Halina Dobrzynski   +3 more
doaj   +1 more source

Sans papier et sans encre [PDF]

Cahiers de littérature orale, 2007
L’article décrit et analyse le motif de la lettre dans les chansons françaises de tradition orale. Alors que les livres n’y sont presque jamais mentionnés, les références à des lettres, billets ou autres « mots d’écrit » abondent dans les chansons recueillies par les folkloristes, au point qu’on peut se demander ce qui fait sens, pour ceux qui les ...
openaire   +1 more source

A Climate-Mathematical Clustering of Rainfall Stations in the Río Bravo-San Juan Basin (Mexico) by Using the Higuchi Fractal Dimension and the Hurst Exponent [PDF]

, 2021
Francisco Gerardo Benavides-Bravo, Dulce Martinez-Peón, Ángela Gabriela Benavides-Ríos, Otoniel Walle-García, Roberto Soto-Villalobos, Mario A. Aguirre-López   +5 more
openalex   +1 more source

Symplectic Techniques for Semiclassical Completely Integrable Systems

, 2004
This article is a survey of classical and quantum completely integrable systems from the viewpoint of local ``phase space'' analysis. It advocates the use of normal forms and shows how to get global information from glueing local pieces.
Ngoc, San Vu
core   +1 more source