Results 81 to 90 of about 7,676,917 (278)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Existencia y alcance de la obligación de renegociar la extinción unilateral del contrato
Revista Jurídica AustralEl tercer párrafo del artículo 1011 del Código Civil y Comercial de la Argentina impone a la parte que quiere rescindir un contrato de duración la obligación de renegociar el tema previamente.
Andrés Sánchez Herrero
doaj +1 more source
Di sản và vấn đề giáo dục di sản cho học sinh trung học phổ thông
Tạp chí Khoa học Đại học Cần Thơ, 2019 Nghiên cứu về di sản và giáo dục di sản trong trường phổ thông, trước hết cần nhận dạng được di sản với 3 nhóm gồm di sản thiên nhiên, di sản văn hóa và di sản hỗn hợp. Mỗi di sản được phân loại đều có tiêu chí rõ ràng, những di sản được UNESCO công nhận
Dương Quỳnh Phương +1 more
doaj +1 more source
Decoding of Quasi-Cyclic Codes up to A New Lower Bound on the Minimum Distance
, 2014 A new lower bound on the minimum Hamming distance of linear quasi-cyclic codes over finite fields is proposed. It is based on spectral analysis and generalizes the Semenov- Trifonov bound in a similar way as the Hartmann-Tzeng bound extends the BCH ...
Ling, San, Zeh, Alexander
core +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Computational assessment of the functional role of sinoatrial node exit pathways in the human heart.
PLoS ONE, 2017 AimThe human right atrium and sinoatrial node (SAN) anatomy is complex. Optical mapping experiments suggest that the SAN is functionally insulated from atrial tissue except at discrete SAN-atrial electrical junctions called SAN exit pathways, SEPs ...
Sanjay R Kharche +3 more
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Les Cahiers philosophiques de StrasbourgJe rappelle ici l’une des plus constantes préoccupations de la pensée de Jean-Luc Nancy : celle du destin d’un Occident qui, au moment même où il paraît accomplir son élargissement au monde entier, est amené à faire, de plus en plus, le constat de son propre effacement, de son déclin, ou de sa finitude. Je le fais tout en déplaçant quelque peu le point
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Sans papier et sans encre [PDF]
Cahiers de littérature orale, 2007 L’article décrit et analyse le motif de la lettre dans les chansons françaises de tradition orale. Alors que les livres n’y sont presque jamais mentionnés, les références à des lettres, billets ou autres « mots d’écrit » abondent dans les chansons recueillies par les folkloristes, au point qu’on peut se demander ce qui fait sens, pour ceux qui les ...
openaire +1 more source