Results 121 to 130 of about 376,994 (273)

Fairness, Sanction, and Condemnation [PDF]

open access: yes
I here press an often overlooked question: Why does the fairness of a sanction require an adequate opportunity to avoid it? By pressing this question, I believe I have come to better understand something that has long puzzled me, namely, what ...
Hieronymi, Pamela
core  

Development of a reoffending measure using the Police National Computer database. [PDF]

open access: yes, 2007
This work aims to develop a reoffending score for assessing the likelihood of an offender reoffending within a certain fixed period of time. Currently, OGRS - the Offenders Group Reconviction Score - is a heavily used measure for assessing reconviction ...
Francis, Brian   +2 more
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

THE MORE FAVORABLE CONTRAVENTION LAW IN THE CONTEXT OF RO-E-TRANSPORT: CHALLENGES AND CRITICAL CONSIDERATIONS [PDF]

open access: yesChallenges of the Knowledge Society
The year 2024 was an extremely dynamic one regarding the changes made to the GEO no. 41/2022, which establishes the national system for monitoring road freight transport, RO-e-transport, particularly concerning the sanctioning regime.
Narcisa-Victoria DĂRĂBAN
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

El acceso a la vivienda y la nueva función social del derecho de propiedad

open access: yesRevista Vasca de Administración Pública, 2014
The serious problem of access to housing in our country gives moreover the contradiction of having a plentiful stock of empty houses. In the face of this situation some autonomic legislators have resorted to a new concept of social function of urban ...
Joaquín Tornos Mas
doaj   +1 more source

Work Sanctions Under Welfare Reform: Are They Helping Women Achieve Self-Sufficiency? [PDF]

open access: yes, 2006
The focus of this thesis has been to determine the usable voltage range of carbon-based supercapacitors (SC). Supercapacitors are a relatively new type of capacitors with a vast increase in capacitance compared to capacitors which utilize a dielectric as
Lens, Vicki
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Can Sanctions Induce Pessimism? An Experiment [PDF]

open access: yes
We experimentally investigate the effects of sanctions when there are multiple equilibria. Two subjects play a two-period minimum effort game in the presence of third player (principal).
Joël van der Weele   +2 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

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