Results 161 to 170 of about 27,580 (313)
AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint
Advanced Science, EarlyView.AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz +4 more
wiley +1 more source
ICARDA Policy on Sanctions Management
, 2019 The purpose of the ICARDA Policy on Sanctions Management (Sanctions Policy) is to provide guidance to ICARDA staff on sanctions affecting ICARDA’s activities and how to ensure compliance with binding ...
(ICARDA), International Center for Agricultural Research in the Dry Areas
core
Advanced Science, EarlyView.ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun +10 more
wiley +1 more source
Innocent or not-so-innocent bystanders: evidence from the gravity model of international trade about the effects of UN sanctions on neighbor countries [PDF]
This paper examines two theories about the effects of UN sanctions on trade flows between land neighbors of the target country and the rest of the world.
Slavi T. Slavov
core
Advanced Science, EarlyView.This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng +14 more
wiley +1 more source
Energy sanctions reloaded : navigating the trade-sanctions divide in the EU's proposed gas ban
Published online: 25 June 2025The European Commission proposed a ban on Russian gas imports based on Article 207 TFEU – a legal basis related to the EU’s Common Commercial Policy (CCP), rather than the Common Foreign and Security Policy (CFSP).
SZÉP, Viktor +2 more
core +1 more source
Fiat Justisia, 2015 criminal policy to eradicate crimes against state security in Indonesia by Law Law Number 27 of 1999 include: (1) the criminalization of acts specified as criminal offenses security of the state, namely the spread of the ideology of communism, founded ...
Maroni Maroni
doaj
Advanced Science, EarlyView.Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak +6 more
wiley +1 more source
Advanced Science, EarlyView.Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li +13 more
wiley +1 more source
Sanctions and sovereignty: Venezuela's human health crisis. [PDF]
Ann Med Surg (Lond)Khan AM, Mustafa A, Fatima M.
europepmc +1 more source