Results 131 to 140 of about 2,721 (182)

Disposition of sanguinarine in the rat

Xenobiotica, 2007
Sanguinarine is an alkaloid with known antibiotic and anti-inflammatory activity and its pharmacokinetics have been studied in the rat after a single oral dose (10 mg kg(-1) body weight). Alkaloid determination in the plasma and liver was carried out by high-performance liquid chromatography-electrospray ionization mass spectrometry (HPLC/ESI-MS).
R, Vecera, B, Klejdus, P, Kosina, J, Orolin, M, Stiborová, S, Smrcek, J, Vicar, Z, Dvorák, J, Ulrichová, V, Kubán, P, Anzenbacher, V, Simánek   +11 more
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Sensitivity of vibrios to sanguinarine

Experientia, 1983
The sensitivity to sanguinarine of various strains belonging to 4 vibrio biotypes was investigated.Vibrio cholerae (classical) was most sensitive, andVibrio parahaemolyticus least sensitive to this alkaloid. Statistical analysis revealed significant differences between the 4 biotypes in their sensitivity to sanguinarine.
R, Nandi, M, Maiti, K, Chaudhuri, S B, Mahato, A K, Bairagi   +4 more
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Metabolism of Sanguinarine: The Facts and The Myths

Current Drug Metabolism, 2007
Sanguinarine, a quaternary benzo[c]phenanthridine alkaloid, exhibits antimicrobial and anti-inflammatory activities and for this reason it is used in dental hygiene products and feed additives. Its metabolism and disposition is the subject of constant scientific discourse. In this paper we summarize current knowledge on sanguinarine metabolism. We show
Z, Dvorák, V, Simánek
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Anticancer Perspectives of Sanguinarine: A Review

Current Bioactive Compounds, 2022
Background: Sanguinarine, a benzophenanthridine alkaloid extracted from Sanguinaria canadensis has been found to show an inhibitory role on proapoptotic and growth inhibitory activities in various tumor cells of experimental subjects. Objective: This review highlights and summarizes the effects of sanguinarine against cancers alongside the possible ...
Syed Amir Gilani, null Iahtisham-Ul-Haq, Muhammad Imran, Tanweer Aslam Gondal, Ishtiaque Ahmad, Aqsa Akram   +5 more
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PHOTOTOXIC AND PHOTOCHEMICAL PROPERTIES OF SANGUINARINE*

Photochemistry and Photobiology, 1992
Abstract— Sanguinarine, a commercial drug exhibiting antimicrobial and antitumor properties, was studied with respect to its basic photochemical characteristics and also with regard to its phototoxicity to mosquito larvae (Aedes atropalpus). Sanguinarine proved to be clearly phototoxic to larvae, with an LD50 of 0.096 mg/mL with near UV exposure as ...
J T, Arnason, B, Guèrin, M M, Kraml, B, Mehta, R W, Redmond, J C, Scaiano   +5 more
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Isolation from Argemone Oil of Dihydrosanguinarine and Sanguinarine : Toxicity of Sanguinarine

Nature, 1948
ARGEMONE oil has received considerable attention during recent years on account of its alleged etiological role in epidemic dropsy1-4. I pointed out5 certain anomalies of the mustard oil - argemone oil theory of epidemic dropsy and stressed the fact that a definite solution of the problem could only be arrived at by isolating the active principle from ...
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Structure of Sanguinarine Base

Journal of Natural Products, 1996
The structure of sanguinarine free base was examined. The base is either bis[6-(5,6-dihydrosanguinarinyl)] ether (3) or bis[6-(5,6-dihydrosanguinarinyl)]amine (4) depending on whether Na2CO3 or NH3, respectively, is used as an alkalizing agent.
Jiří Dostál, Hana Bochořáková, Eva Táborská, Jiří Slavík, Milan Potáček, Miloš Buděšínský, Edmond de Hoffmann   +6 more
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Sanguinarine: an evaluation of in vivo cytogenetic activity

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2004
Sanguinarine (SG), a benzophenanthridine alkaloid, has been shown to possess anti-microbial, anti-inflammatory and antioxidant properties. In the UK and USA its salts has been in use in mouthwashes and toothpastes to inhibit dental plaque and improve gingival health.
Aparajita, Das, Anita, Mukherjee, J, Chakrabarti   +2 more
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Suppression of angiogenesis by the plant alkaloid, sanguinarine

Biochemical and Biophysical Research Communications, 2004
Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis. Its principal pharmacologic use is in dental products where it has antibacterial, antifungal, and anti-inflammatory activities that reduce gingival inflammation and supragingival plaque formation.
Eun, JP, Koh, GY Koh, Gou Young
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Sanguinarine and Its Role in Chronic Diseases

2016
The use of natural products derived from plants as medicines precedes even the recorded human history. In the past few years there were renewed interests in developing natural compounds and understanding their target specificity for drug development for many devastating human diseases.
Pritha, Basu, Gopinatha Suresh, Kumar
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