Results 21 to 30 of about 8,508 (236)

From the Gut to the Bone: A Narrative Review of the Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO)-Inflammatory Bowel Disease (IBD) Overlap Syndrome. [PDF]

Cureus
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoinflammatory disorder primarily affecting the musculoskeletal system and skin.
Almalaq AA, Almasoud A, Almeghaiseeb E, Alamro R, Albishi AM, Alrashidi S, Alrobayan A.   +6 more
europepmc   +2 more sources

Abundance alteration of nondominant species in fecal-associated microbiome of patients with SAPHO syndrome

BMC Microbiology, 2021
Background SAPHO syndrome is a group of symptoms consisting of synovitis, acne, pustulosis, hyperostosis and osteosis. There is no specific laboratory index assist in the diagnosis of SAPHO because of its highly heterogeneous clinical manifestations ...
Jianhua Zhen, Yuxiu Sun, Pengfei Zhao, Chen Li, Hesong Wang, Yini Li, Lu Zhao, Li Wang, Guangrui Huang, Anlong Xu   +9 more
doaj   +1 more source

What Is New and What Is Next for SAPHO Syndrome Management: A Narrative Review. [PDF]

J Clin Med
Synovitis–acne–pustulosis–hyperostosis–osteitis (SAPHO) syndrome is a rare disease characterized by a sterile inflammatory osteitis and/or arthritis associated with a wide range of dermatological manifestations, such as acne, palmoplantar pustulosis, and
Ferraioli M, Levani J, De Luca R, Matucci-Cerinic C, Gattorno M, Guiducci S, Bellando Randone S, Chimenti MS.   +7 more
europepmc   +2 more sources

SAPHO Syndrome Complicated by Ankylosing Spondylitis Successfully Treated With Tofacitinib: A Case Report

Frontiers in Immunology, 2022
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, a type of chronic inflammatory disease, is rare and difficult to treat. Osteoarthropathy with skin involvement is the primary clinical manifestation of SAPHO syndrome.
Fangfang Yuan, Jing Luo, Qiong Yang
doaj   +1 more source

Serum-derived extracellular vesicles inhibit osteoclastogenesis in active-phase patients with SAPHO syndrome

Therapeutic Advances in Musculoskeletal Disease, 2021
Objective: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disorder and the underlying pathogenesis is unclear.
Yanpan Gao, Yanyu Chen, Lun Wang, Chen Li, Wei Ge   +4 more
doaj   +1 more source

A Case of Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome With Myeloperoxidase Anti-neutrophil Cytoplasmic Antibody: Exploring an Association or Coincidence. [PDF]

Cureus
We report the first documented case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome in a Japanese male with positive serum myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA).
Kimura K, Hayashi K, Suzuki A, Sato M, Nakaya Y, Takaku N, Miura T, Kobayashi Y.   +7 more
europepmc   +2 more sources

Dental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature review. [PDF]

BMC Nephrol
Exposure to metals is associated with adverse health effects, including multiorgan damage and dysregulation of systemic immune responses. The increasing use of metallic implants in humans, such as dental materials and orthopedic devices, has resulted in ...
Cai Y, You Q, Jiang W, Liu X, Shao L.
europepmc   +2 more sources

Takayasu arteritis complicated by SAPHO syndrome: A case-based review. [PDF]

Clin Rheumatol
Takayasu arteritis (TAK) is often associated with other inflammatory diseases. Here, we describe two Japanese patients with TAK complicated by synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Both patients presented with anterior
Sugimoto S, Kishida D, Kobayashi T, Tanomogi N, Kurashina JI, Ichikawa T, Shimojima Y, Sekijima Y.   +7 more
europepmc   +2 more sources

SAPHO syndrome complicated by IgG4-related ophthalmic disease: a case report and literature review. [PDF]

Front Immunol
Introduction Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an extremely rare condition with nonspecific clinical signs and symptoms.
Liu C, Chen T, Wang Y, Wang Q, Hu H, Chen H.   +5 more
europepmc   +2 more sources

Severe osteoarticular involvement in isotretinoin-triggered acne fulminans: two cases successfully treated with anakinra. [PDF]

, 2017
Acne fulminans (AF) is a severe form of inflammatory and ulcerated acne associated with fever, malaise, joint swellings and polyarthralgia.1 Osteoarticular lesions are often described and can be radiologically indistinguishable from those observed in
Barbareschi, Cassel, Colina, Firinu, Firinu, Laasonen, Nast, Nguyen, Wendling, Zaba   +9 more
core   +1 more source