Results 111 to 120 of about 82,181 (261)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Characterization of saponin biotransformation driven by intrinsic proteins in <i>Aralia elata</i> leaves. [PDF]

Food Chem X
Guo KW, Ma LJ, Kan YX, Zhang JJ, Zhang FX, Wan JB.   +5 more
europepmc   +1 more source

Decoding Molecular Mechanisms of Pongamia pinnata Phytochemicals in Cancer Therapy

Medicine Advances, EarlyView.
Pongamia pinnata phytochemicals have multiple anticancer mechanisms, including antioxidant, anti‐inflammatory, anti‐metastatic, and apoptosis‐inducing activities through molecular‐level regulation. These bioactive compounds protect normal cells from oxidative stress while promoting reactive oxygen species‐mediated tumor cell death and suppressing ...
Rajib Dhar, Vetriselvan Subramaniyan
wiley   +1 more source

Establishment and optimization of hairy root cultures of Acanthophyllum species: a novel platform for enhanced saponin production. [PDF]

BMC Plant Biol
Arabjafari S, Bashari H, Golkar P, Yousefian Z, Mirjalili MH.   +4 more
europepmc   +1 more source

From wild to tamed: Reimagining novel crops through omics and local plant diversity

PLANTS, PEOPLE, PLANET, EarlyView.
The global food system faces growing pressure from climate change, biodiversity loss, and rising nutritional demands. Agriculture has increased yields but reduced crop diversity, flavor, and nutritional quality, leaving societies vulnerable and dependent on a narrow set of staple species.
Alexandra Sanfeliu Meliá, Pablo D. Cárdenas   +1 more
wiley   +1 more source

Adjuvant choice shapes macrophage activation and cytokine responses to freeze-thaw breast cancer antigens. [PDF]

BMC Res Notes
Ihlamur M, Abamor EŞ.
europepmc   +1 more source

Chemical diversity and phylogenetic insights into Hawaiian ʻākia (Wikstroemia) species used in traditional fishing practices

PLANTS, PEOPLE, PLANET, EarlyView.
Traditional fishing with plant‐based piscicides is a global practice in decline, facing increasing restrictions. We investigated the chemical diversity of endemic Wikstroemia species historically used to stun or poison fish in Hawaiʻi. Using 1‐H‐NMR, principal component analysis, targeted HPLC, and target‐capture sequencing, we characterized compounds ...
Louise Winther, Isaac Lichter‐Marck, Louise Kjaerulff, David Lorence, Uma Nagendra, Mike Opgenorth, Sverre J. Schou, Kenneth R. Wood, Felipe Zapata, Dan Staerk, Nina Rønsted   +10 more
wiley   +1 more source

Programmable saponin biosynthesis from gene networks to predictive biomanufacturing. [PDF]

Front Plant Sci
Wang Y, Chen J, Liao Z, Yin L, Shi F, He G, Liao Y.   +6 more
europepmc   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Development and optimization of host DNA depletion in blood cultures using a saponin and salt-activated nuclease-based method. [PDF]

Front Microbiol
Ali J, Bellankimath AB, Hira J, Chapagain C, Opgård ST, Simonsen GS, Ahmad R.   +6 more
europepmc   +1 more source