Results 131 to 140 of about 79,911 (264)

Processing methods and mechanisms for saponin-rich traditional Chinese medicines: a review. [PDF]

Chin Med
Tian SQ, Wang XT, Wang YZ, Shi JQ, Gao H.   +4 more
europepmc   +1 more source

Mitochondrial respiration and hydrogen peroxide production rate in right atrial tissues from obese diabetic patients

Experimental Physiology, EarlyView.
Abstract Type 2 diabetes (T2D) is a global epidemic, with heart failure being the leading cause of premature death. Mitochondrial dysfunction, characterized by impaired energy metabolism, weakened energy transport system and increased oxidative stress, has been proposed as a key contributor to the impairment of contractile function in T2D hearts ...
Toan Pham, Sarbjot Kaur, Anthony Hickey, Marie‐Louise Ward, Kenneth Tran   +4 more
wiley   +1 more source

Descriptor-Guided Selection of Extracellular Vesicle Loading Strategies for Small-Molecule Drug Delivery: A Mechanistically Interpretable Decision-Support Framework. [PDF]

Pharmaceutics
Zelkó R, Kazsoki A.
europepmc   +1 more source

Therapeutic potential of okra (Abelmoschus esculentus) in dysglycaemia and metabolic dysfunction: A systematic review and meta‐analysis across the diabetes spectrum

Experimental Physiology, EarlyView.
Abstract The aim of this systematic review and meta‐analysis was to evaluate comprehensively the therapeutic potential of Abelmoschus esculentus (okra) supplementation across the diabetes spectrum of key metabolic risk factors. A search was conducted in PubMed, Scopus, Web of Science, EMBASE and the Cochrane Library, up to 23 July 2025, to identify ...
Ali Jafari, Helia Mardani, Mohammad Amin Karimi, MohammadHossein Sahami Gilan, Helia Hemmat, Fatemeh Shoja, Nooshin Enayati Soofi, Ghazaleh Eslamian   +7 more
wiley   +1 more source

Rhizosphere fungal generalists drive plant metabolic adaptability via regulating soil micronutrient availability. [PDF]

Environ Microbiome
Zhang G, Ma J, Xiong G, Wei G, Luo Z, Gao L, Shi L, Huang L, Liu Y, Yang M, Zheng J, Zheng Y, Wei X, Wang Y, Dong L.   +14 more
europepmc   +1 more source

Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa

Experimental Physiology, EarlyView.
Abstract Anorexia nervosa (AN) is a psychiatric disorder characterized by prolonged caloric restriction and skeletal muscle atrophy. Mitochondrial health is a key mediator of muscle function, yet the role of mitochondria during AN and following weight regain has not been investigated. The objective of this study was to evaluate mitochondrial capacities
Megan E. Rosa‐Caldwell, Toby L. Chambers, Lauren Breithaupt, Ruqaiza Muhyudin, Patience Salvalina Okoto, Sadie R. Thompson, Emily E. Rothacker, Claire Greenhill, Katie A. Wood, Kevin A. Murach, Sarah H. White‐Springer, Ursula B. Kaiser, Seward B. Rutkove   +12 more
wiley   +1 more source

Comparative evaluation of a multi-functional dust suppressant synthesized from Sapindus mukorossi extract and bentonite clay. [PDF]

Sci Rep
Kumar P, Diddi S, Ramachandra S, Uppara HP.   +3 more
europepmc   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

Structure and immunological activity of QS-21 variant from <i>Quillaja saponaria</i> aerial biomass. [PDF]

Front Immunol
San Martín R, Liu Y, Yang Y, Fox CB, Iyer LR, Mohamath R, Ramer-Denisoff G, Kinsey R, Guderian JA, Schwabach J, Deng S, Fernandes NAT, Radke C.   +12 more
europepmc   +1 more source