Results 51 to 60 of about 110,649 (250)

Magnetic Nanoparticle-Based Dianthin Targeting for Controlled Drug Release Using the Endosomal Escape Enhancer SO1861

Nanomaterials, 2021
Targeted tumor therapy can provide the basis for the inhibition of tumor growth. However, a number of toxin-based therapeutics lack efficacy because of insufficient endosomal escape after being internalized by endocytosis.
Ajmal Zarinwall, Mazdak Asadian-Birjand, Didem Ag Seleci, Viktor Maurer, Alexandra Trautner, Georg Garnweitner, Hendrik Fuchs   +6 more
doaj   +1 more source

Saponin : Dampak terhadap Ternak (Ulasan) [PDF]

, 2017
Saponin merupakan senyawa glikosida steroid atau triterpen ditemukan dalam berbagai tanaman dan memiliki peran penting dalam pakan ternak. Beberapa tanaman terutama leguminosa banyak digunakan sebagai pakan ternak. Pada tanaman saponin terdapat pada akar,
Purnamaningsih, H., ., Yanuartono, Nururrozi, A., Indarjulianto, S., Indarjulianto, Soedarmanto, Purnamaningsih, Hary, Nururrozi, Alfarisa, Yanuartono, Yanuartono   +7 more
core   +1 more source

Tailored Covalent Organic Frameworks Enable the Encapsulation of Living Cells to Produce Rare Ginsenoside

Advanced Science, EarlyView.
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu, Shan Zhang, Shanrong Wei, Ziye Xing, Hongming He, Xiao Liang, Quanshun Li   +6 more
wiley   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway

Pharmaceutical Biology, 2023
Context Panax ginseng C. A. Meyer (Araliaceae) is a tonic herb used in ancient Asia.Objective This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats.Materials and methods Sprague-Dawley rats were divided into control, model ...
Guolei Zhang, BoFan Lu, Enhui Wang, Wei Wang, Zheng Li, Lili Jiao, Hui Li, Wei Wu   +7 more
doaj   +1 more source

Saponin Biosynthesis in Pulses

, 2022
Pulses are a group of leguminous crops that are harvested solely for their dry seeds. As the demand for plant-based proteins grows, pulses are becoming important food crops worldwide.
Nii Patterson, Yu, Bianyun, Zaharia, L. Irina, Bianyun Yu, L. Irina Zaharia, Patterson, Nii   +5 more
core   +1 more source

Multifunctional Zinc Glycyrrhizinate‐Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis

Advanced Science, EarlyView.
Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng, Xiaochun Chen, Wei Li, Shu Tang, Jun Zhou, Xia Wu, Dan Yuan, Zhongyan Shan, Junfeng Shi   +8 more
wiley   +1 more source

Effective Search of Triterpenes with Anti-HSV-1 Activity Using a Classification Model by Logistic Regression

Frontiers in Chemistry, 2021
Natural products are an excellent source of skeletons for medicinal seeds. Triterpenes and saponins are representative natural products that exhibit anti-herpes simplex virus type 1 (HSV-1) activity.
Keiko Ogawa, Seikou Nakamura, Haruka Oguri, Kaori Ryu, Taichi Yoneda, Rumiko Hosoki   +5 more
doaj   +1 more source

Separation of Saponin Using Nanofiltration Membrane [PDF]

, 2021
Separation of pure saponin and saponin-BSA protein mixture by nanofiltration membranes have been investigated in this study to understand the nanofiltration potential to obtain high purity saponin.
Hamada, Nur 'Aini, Emzar, Ilham Dwiyanto, Listyadevi, Yuniar Luthfia   +2 more
core  

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source