Results 231 to 240 of about 105,044 (309)

Comprehensive Identification and Abscisic Acid-Responsive Expression Profiling of NAC Transcription Factor in Triterpenoid Saponin in <i>Hedera helix</i>. [PDF]

Biomolecules
Deng X, Zheng F, Xu Z, Mao X, Yu Z, Shen X.   +5 more
europepmc   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, Volume 13, Issue 14, 9 March 2026.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

Functional characterization of a novel β-glucosidase converting trillin to diosgenin from Enterococcus faecalis. [PDF]

Microb Cell Fact
Zhou C, Zhu M, Li Q, Deng W, Sun N, Liu W, Li Y, Wang X, Zhang F, Li L, Li J.   +10 more
europepmc   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

GAME15: a pivotal nexus unlocking solanum alkaloid metabolism and biosynthesis underpinning the chemical defense and pharmacological potential in Solanum species. [PDF]

Front Plant Sci
Li X, Feng Y, He W, Tuo S, Chen G, Sun J, Li Z, Zhong K, Luo W, Kong B.   +9 more
europepmc   +1 more source

Indirect identification of 4,21-dehydrocorynenantheinaldehyde as an intermediate in the biosynthesis of ajmalicine and related alkaloids [PDF]

, 1978
Hoyer, G. A., Rüffer, Martina, Stöckigt, Joachim, Zenk, Meinhart H.   +3 more
core  

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Molluscicidal Activity of <i>Camellia Sinensis</i> (Green Tea) and <i>Camellia sinensis</i> var. Assamica (Purple Tea) Extracts Against <i>Biomphalaria pfeifferi,</i> the Major Vector Snail of Human Schistosomiasis in Sub-Saharan Africa. [PDF]

J Parasitol Res
Samoo N, Nyangacha R, Mbugua A, Mwangi I, Syengo CK, Laidemitt M, Mutuku M.   +6 more
europepmc   +1 more source

Dual‐Anchored Clickable Peptide via SPAAC for Gelatinase‐Responsive Antibacterial and Osteogenic Functions on Titanium Implants

Advanced Science, Volume 13, Issue 14, 9 March 2026.
To address the infection‐associated orthopedic implant failures, this study presents a gelatinase‐responsive antibacterial titanium implant (Ti‐Dual) featuring a dual‐anchored fusion peptide containing antibacterial (HHC36) and osteogenic (RGD) domains connected by a cleavable GPLGV linker.
Ru Zhong, Hang Zhou, Chenyang Ye, Lei Chu, Lin Wang, Yingjun Wang   +5 more
wiley   +1 more source