Results 81 to 90 of about 11,005 (207)

Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism

Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.
Loss of intestinal epithelial fucosylation exacerbates alcohol‐related liver injuries. Intestinal epithelial deletion of Fut2 disrupts nicotinamide (NAM) metabolism due to the decline in bacterial nicotinamidase (PncA). Supplemented with pncA overexpressed E.coli to restore gut PncA levels can improve liver damage in alcohol‐induced intestinal ...
Liuying Chen, Zhongwei Yin, Luorui Shang, Hang Yuan, Wenkang Gao, Shuhan Wang, Shuyan Wang, Xiaohua Hou, Shenglan Yang, Huikuan Chu   +9 more
wiley   +1 more source

Viral Reprogramming of Nucleotide Synthesis and Its Impact on Viral Infection

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Nucleotides are the building blocks of DNA and RNA. They also play essential roles in various other biological processes, including protein glycosylation, ribosome biogenesis, and cytoskeletal function. The significance of the regulation of nucleotide metabolism has recently gained more attention in many physiological and pathological contexts,
Lara Dsouza, Zhilong Yang
wiley   +1 more source

Human Norovirus prevalence in Africa:a review of studies from 1990 to 2013 [PDF]

, 2016
OBJECTIVES: To assess the contribution of Human Norovirus to diarrheal diseases in Africa.   METHODS: We conducted a systematic review of the PubMed and EMBASE databases for published articles of Human Norovirus in Africa between 1990 and 2013. Data were
Abugalia, Ahenda, Ahmed, Armah, Asten, Atmar, Atmar, Ayukekbong, Ayukekbong, Azenabor, Benabbes, Boschi-Pinto, Bucardo, Bull, CDC-Division of viral diseases, Cegielski, Centers for Disease Control and Prevention (CDC), Centers for Disease Control and Prevention (CDC), Charles, Daniels, Dove, Duizer, El-Mohammady, El-Senousy, Elamri, Ferreira, Gibson, Green, Green, Greenberg, Hall, Hanoman, Hassine-Zaafrane, Hoa Tran, Huynen, Iwai, Jiang, Kabayiza, Kamel, Kamel, Kapikian, Karst, Kiulia, Kotloff, Kremer, Krumkamp, Kukkula, Le Guyader, Lee, Lindesmith, Liu, Liu, Lopman, Lysén, Mans, Mans, Maslin, Matthews, Mattison, Maunula, Medici, Milbrath, Mitchell, Moyo, Moyo, Murray, Nakata, Nordgren, Nourlil, Oluwatoyin, Papaventsis, Patel, Patel, Pavone, Payne, Pickering, Polo, Pommier de Santi, Rahouma, Ramani, Reither, Reuter, Rockx, Rodriguez-Diaz, Schilling, Sdiri-Loulizi, Sdiri-Loulizi, Sdiri-Loulizi, Seitz, Shieh, Siebenga, Siebenga, Silva, Silverman, Smit, Smit, Taylor, Taylor, Taylor, Thea, Trainor, Trujillo, Uhnoo, Wolfaardt, Wolfaardt, Xi, Yassin, Zeng, Zheng   +108 more
core   +1 more source

Unveiling Viruses Associated with Gastroenteritis Using a Metagenomics Approach

Viruses, 2020
Acute infectious gastroenteritis is an important illness worldwide, especially on children, with viruses accounting for approximately 70% of the acute cases.
Xavier Fernandez-Cassi, Sandra Martínez-Puchol, Marcelle Silva-Sales, Thais Cornejo, Rosa Bartolome, Silvia Bofill-Mas, Rosina Girones   +6 more
doaj   +1 more source

Human sapovirus GI.2 and GI.3 from children with acute gastroenteritis in northern Brazil

Memorias do Instituto Oswaldo Cruz, 2019
Human sapoviruses (HSaV) are considered important causative agents of acute gastroenteritis in humans worldwide. However, knowledge of the genetic characteristics of the whole genome of HSaV in Brazil is limited.
Audrey Cilli, Adriana Luchs, Elcio Leal, Danielle Gill, Flavio Augusto de Pádua Milagres, Shirley Vasconcelos Komninakis, Rafael Brustulin, Maria da Aparecida Rodrigues Teles, Márcia Cristina Alves Brito Sayão Lobato, Rogério Togisaki das Chagas, Maria de Fátima Neves dos Santos Abrão, Cassia Vitória de Deus Alves Soares, Xutao Deng, Eric Delwart, Ester Cerdeira Sabino, Antonio Charlys da Costa   +15 more
doaj   +1 more source

Establishment of a Novel Caco‐2‐Based Cell Culture System for Human Sapovirus Propagation

Genes to Cells, Volume 30, Issue 2, March 2025.
We identified that both Caco‐2 cells and in‐house Caco‐2/Cas9 cells are susceptible to human sapovirus (HuSaV) infection. By performing two rounds of single‐cell cloning from Caco‐2/Cas9 cells, we successfully established a highly susceptible cell line, designated as Caco‐2MC.
Yuya Fukuda, Azusa Ishikawa, Ryoka Ishiyama, Reiko Takai‐Todaka, Kei Haga, Yuichi Someya, Tomomi Kimura‐Someya, Kazuhiko Katayama   +7 more
wiley   +1 more source

Impact of Hepatoblastoma on Infectious Complications Following Pediatric Liver Transplantation

Pediatric Transplantation, Volume 29, Issue 1, February 2025.
Our single‐center retrospective study of pediatric patients following liver transplantation (pLT) found that hepatoblastoma (HB) patients had the most infectious events (IE) per patient and were more likely to develop fever & neutropenia than patients with biliary atresia or other hepatic diseases.
Ashton D. Hall, Hope A. Hendricks, Katherine A. Bowers, James I. Geller, Alexander J. Bondoc, Greg M. Tiao, Amy E. Taylor, William R. Otto, Grant C. Paulsen, Lara A. Danziger‐Isakov   +9 more
wiley   +1 more source

Children hospitalised with gastroenteritis before and during the COVID‐19 pandemic

Acta Paediatrica, Volume 114, Issue 1, Page 148-155, January 2025.
Abstract Aims The COVID‐19 pandemic altered the pattern of many paediatric infections. We aimed to assess the incidence and characteristics of children hospitalised with gastroenteritis during the early and the late pandemic, relative to previous years. Methods In a retrospective study, we collected data from patient files of children aged 1 month to 5 
Hamida Saidian, Rie Daugberg, Lise Heilmann Jensen, Ann‐Marie Malby Schoos, Maren Johanne Heilskov Rytter   +4 more
wiley   +1 more source

Drug‐Induced Liver Failure Following Topical Minoxidil: A Case Report

Case Reports in Gastrointestinal Medicine, Volume 2025, Issue 1, 2025.
Introduction Drug‐induced liver failure (DILI) is one of the causes of acute liver injury (13%–20%), encompassing both predictable and idiosyncratic reactions. While the latter are rare, it can lead to severe liver damage in vulnerable patients. Although topical minoxidil is a widely used treatment for androgenetic alopecia, cases of liver failure ...
Katrin Premke, Matthias Kästner, Carlos Fritzsche, Andreas Erbersdobler, Micha Loebermann, Marcel Cc Machado   +5 more
wiley   +1 more source

An Unusual Case of Ileitis and Partial Small Bowel Obstruction Secondary to Mesh Erosion After Totally Extraperitoneal Inguinal Hernia Repair

Case Reports in Gastrointestinal Medicine, Volume 2025, Issue 1, 2025.
The objectives were to highlight that: (1) mesh erosion related partial small bowel obstruction after laparoscopic totally extraperitoneal (TEP) inguinal hernia repair (IHR) as an uncommon complication can clinically and radiologically mimic ileocolic Crohn’s disease in young adults; and (2) implore clinicians to consider a broad set of differential ...
Pranesh de Silva, Joseph Do Woong Choi, Craig Lynch, Stephen Pillinger, Saurabh Gupta, Praveen Ravindran, Yoshifumi Nakayama   +6 more
wiley   +1 more source