Results 51 to 60 of about 254,830 (314)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

Synthesis and Activity of New Schiff Bases of Furocoumarin

open access: yesHeterocyclic Communications, 2020
Furocoumarins, such as 8-MOP, are the most common medications used to relieve the symptoms of vitiligo clinically. Some furocoumarins also showed excellent performance in an anti-bacterial assay.
Xie Huijun   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Insights from Comparative Analysis of Radar and Optical Vegetation Indices: A Case Study in Gilan Province, Iran

open access: yesEkológia (Bratislava)
This study evaluates the relationships between Sentinel-1 radar vegetation indices (modified radar vegetation index [mRVI], modified Radar Forest Degradation Index [mRFDI]) and Sentinel-2 optical indices (normalized differential vegetation index [NDVI ...
Beirami Behnam Asghari   +1 more
doaj   +1 more source

Screening for Small Molecule Modulators of Trypanosoma brucei Hsp70 Chaperone Activity Based upon Alcyonarian Coral-Derived Natural Products

open access: yesMarine Drugs, 2020
The Trypanosoma brucei Hsp70/J-protein machinery plays an essential role in survival, differentiation, and pathogenesis of the protozoan parasite, and is an emerging target against African Trypanosomiasis.
Sarah K. Andreassend   +4 more
doaj   +1 more source

KINITEC DESCRIPTION OF SODIUM BEHAVIOR IN SOME AFFECTED AND NON-AFFECTED SOILS BY SALTS [PDF]

open access: yesMesopotamia Journal of Agriculture, 2019
This study included different soil locations around Mosul city representing non salt affected soils, and around Basrah city representing salt – affected soil.
Hazim M. Ahmed, Einas Y. Yousif
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Spaceborne Reflector SAR Systems with Digital Beamforming

open access: yes, 2012
Spaceborne Synthetic Aperture Radar (SAR) imaging enters an era where increasingly short revisit times, or large swath widths, respectively, and high spatial resolutions are requested.
Patyuchenko, Anton   +4 more
core   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

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