Results 101 to 110 of about 21,278 (246)

Inhibition of GLUT4 translocation to the sarcolemma by knockdown of Akt2. [PDF]

, 2019
(a) Expression vectors for GLUT4myc7-GFP, Myr-p110α, Rac1(G12V), together with either one of two siRNA duplexes against mouse Akt2 (#1 and #2) and a mixture of NC siRNA duplexes, were introduced into gastrocnemius muscle of wild-type mice. Insulin (175.5
Natsumi Araki (6316742), Nobuyuki Takenaka (636704), Takaya Satoh (164614)   +2 more
core   +1 more source

Defects in integrin complex formation promote CHKB -mediated muscular dystrophy

Life Science Alliance
A decrease in choline kinase activity results in PI(4,5)P2 probe redistribution off the plasma membrane resulting in PI(4,5)P2 binding components of the integrin-vinculin-talin complex no longer binding to the plasma membrane/extracellular matrix thus ...
Mahtab Tavasoli, Christopher R McMaster
doaj   +1 more source

Cellular mechanisms of radiation‐induced myocyte dysfunction: effects on calcium handling, ion channel regulation and mitochondrial energetics

The Journal of Physiology, EarlyView.
Abstract figure legend Dose‐dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate an ROS–Ca2+ positive feedback loop involving calcium/calmodulin‐dependent protein kinase II (CaMKII) activation, enhanced L‐type Ca2+ current (ICaL ...
Hannah M. Zukowski, Colleen E. Clancy
wiley   +1 more source

Characteristics of saxitoxin binding to the sodium channel of sarcolemma isolated from rat skeletal muscle. [PDF]

, 1979
1. The characteristics of saxitoxin (STX) binding to the mammalian Na channel have been studied in purified sarcolemma isolated from rat skeletal muscle. 2. STX binds specifically to isolated sarcolemma with a Kd of 1.43 x 10(-9) M and Bmax of 7-8 p-mole
Barchi, R L, Weigele, J B
core  

Dystrophin and sarcolemma proteins intensities used in single and double labelling. [PDF]

, 2018
Serial sections obtained from two paediatric control muscles (control 1 and 2, Table 1) were used in single or double labelling. (Single labelling: anti dystrophin ab15277, or anti dystrophin MANDYS106; double labelling: anti dystrophin ab15277 combined ...
Francesco Muntoni (228210), Caroline Sewry (3498809), Matthew Ellis (68657), Rahul Phadke (435623), Jennifer E. Morgan (205557), Silvia Torelli (358373), Lucy Feng (435622), Valentina Sardone (540411), Darren Chambers (4348093), Deborah Eastwood (5007509)   +9 more
core   +1 more source

A hypothesis for examining skeletal muscle biopsy derived sarcolemmal nNOSµ as surrogate for enteric nNOSα function

Frontiers in Medicine, 2015
The pathophysiology of gastrointestinal motility disorders is controversial and largely unresolved. This provokes empiric approaches to patient management of these so-called functional gastrointestinal disorders (FGIDs).
Arun eChaudhury
doaj   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Creatine phosphokinase elevation exacerbated by levetiracetam therapy

Epilepsy and Behavior Case Reports, 2014
A 19-year-old muscular male with a history of epilepsy presented following two convulsive events. Levetiracetam (LEV) was given as an additional therapy, resulting in a marked boost in creatine phosphokinase (CPK) that could not easily be explained by ...
Julia E. Isaacson, Dongwhoon J. Choe, Michael J. Doherty   +2 more
doaj   +1 more source

Magnesium-dependent conformational changes of membrane proteins are related to the Mg2+ -dependent ATPase activity in cardiac sarcolemma [PDF]

, 1985
Magnesium-induced enzymatic and structural changes of membrane-bound proteins in rat heart sarcolemma have been investigated. In the absence of ATP, increasing concentrations of magnesium within the range 0.1–10.0 mM gradually lowered the α-helix content
Soos, J., Ziegelhöffer, A., Vrbjar, N., A. Ziegelhöffer, N. Vrbjar, J. Soos   +5 more
core   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source