Results 111 to 120 of about 21,278 (246)
Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy [PDF]
, 1995 Nitric oxide (NO) is synthesized in skeletal muscle by neuronal-type NO synthase (nNOS), which is localized to sarcolemma of fast-twitch fibers. Synthesis of NO in active muscle opposes contractile force. We show that nNOS partitions with skeletal muscle
Ken Aldape +9 more
core +1 more source
CellsLimb–girdle muscular dystrophy R1 (LGMDR1) is characterized by progressive proximal muscle weakness due to mutations in the CAPN3 gene. Little is known about CAPN3’s function in muscle, but its loss results in aberrant sarcomere formation.
Andrea Valls +13 more
doaj +1 more source
When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart
The Journal of Physiology, EarlyView.Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert +6 more
wiley +1 more source
O2 gradients from sarcolemma to cell interior in red muscle at maximal VO2 [PDF]
, 1986 The intracellular distribution of O2 in cross sections of dog gracilis muscles was determined by myoglobin (Mb) cryospectrophotometry. The volume sampled by the photometer was approximately 30 micron3 and contained 1-2 mitochondria.
C. R. Honig, T. E. Gayeski
core +1 more source
Nature Communications, 2019 Thrombospondin 4 has been shown to protect the heart and the skeletal muscle by enhancing matrix secretion and membrane stability thanks to its intracellular function.
Tobias G. Schips +11 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier +3 more
wiley +1 more source
Disruption of the sarcolemma of mammalian skeletal muscle fibers by homogenization [PDF]
, 1975 A new method has been developed for mechanically disrupting the sarcolemma of mammalian sketletal muscle fibers (sarcolemma nonfunctional). Single fibers were produced from small pieces of the soleus muscle of the rabbit by gentle homogenization in a ...
W. G. Kerrick +3 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Illustration of spatial calcium dynamics (left panels) and the state cycle approximation (middle panel) that enables reduced simulation of spatially dependent dynamics without explicit description of space (right panels). The selected example here illustrates a spontaneous calcium wave, showing temporal snapshots of local calcium
Michael A Colman +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mice received chemical injury (cardiotoxin) in the tibialis anterior muscle of one limb, and the contralateral muscle was injected with phosphate‐buffered saline (PBS) as a sham control. Mice then received PBS or mitochondria suspended in PBS into the tail vein.
Stephen E. Alway +6 more
wiley +1 more source
Phosphorylation of the Ca2+-pumping ATPase of heart sarcolemma and erythrocyte plasma membrane by the cAMP-dependent protein kinase. [PDF]
, 1985 peer reviewedThe Ca2+ ATPase of heart sarcolemma was stimulated by the exposure of sarcolemma vesicles to ATP and the catalytic subunit of the cAMP-dependent protein kinase.
Reinlib, L. +2 more
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