Computational evidence for protein-mediated fatty acid transport across the sarcolemma [PDF]
, 2006 Long-chain fatty acids (FAs) are important substrates used by the heart to fulfil its energy requirements. Prior to mitochondrial oxidation, blood-borne FAs must pass through the cell membrane of the cardiac myocyte (sarcolemma). The mechanism underlying
Vusse, van der, G.J. +4 more
core +1 more source
Molecular Therapy: Methods & Clinical DevelopmentMutations in the DYSF gene, encoding the protein dysferlin, lead to several forms of muscular dystrophy. In healthy skeletal muscle, dysferlin concentrates in the transverse tubules and is involved in repairing the sarcolemma and stabilizing Ca2 ...
Joaquin Muriel +10 more
doaj +1 more source
Light‐Driven Quadrupedal Walking Biohybrid Robot With Antagonistic Muscle‐Rings and Inclined Joints
Advanced Robotics Research, EarlyView.This work presents a light‐driven quadrupedal walking biohybrid robot powered by antagonistic muscle‐rings that achieve alternating walking gait. Optical training improved reproducibility of cultured muscle tissues, while caffeine treatment enhanced contractile force.
Shotaro Saito +5 more
wiley +1 more source
Effects of myofiber isolation technique on sarcolemma biomechanics
BioTechniques, 2020 Isolated myofibers are commonly used to understand the function of skeletal muscle in vivo. This can involve single isolated myofibers obtained from dissection or from enzymatic dissociation.
Karla P Garcia-Pelagio +2 more
doaj +1 more source
Proteomics characterization of the cardiac sarcolemma [PDF]
, 2006 As the plasma membrane of the cardiac muscle cell (sarcolemma) plays a major role in the cardiac physiology and homeostasis, the aim of this study is to identify using mass spectrometry (MS) and data base mining the integral and peripheral proteins that ...
Elghawanmeh, Omar.
core
Immunohistochemical demonstration of the binding of bothrops asper myotoxin to skeletal muscle sarcolemma [PDF]
, 1987 The binding of Bothrops asper myotoxin to mouse skeletal muscle was studied at both the light and electron microscope levels using the peroxidase anti-peroxidase technique. The toxin binds to muscle cell sarcolemma, and there are no intracellular binding
Lomonte, Bruno +2 more
core +1 more source
Small-conductance Ca<sup>2</sup>⁺-activated K⁺ channels in cardiac excitation-contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy. [PDF]
J PhysiolAbstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Terentyev D +7 more
europepmc +2 more sources
Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation
Advanced Science, EarlyView.A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou +12 more
wiley +1 more source
TAURINE AND THE CARDIAC SARCOLEMMA. [PDF]
, 1987 Taurine is by far the most abundant of the sulfur amino acids, levels in the heart exceeding the combined quantities of all others. Taurine exhibits extensive cardiovascular pharmacology, including inotropic and antiarrhythmic properties.
SEBRING, LESLIE ANN.
core
Absence of aquaporin-4 in skeletal muscle alters proteins involved in bioenergetic pathways and calcium handling. [PDF]
PLoS ONE, 2011 Aquaporin-4 (AQP4) is a water channel expressed at the sarcolemma of fast-twitch skeletal muscle fibers, whose expression is altered in several forms of muscular dystrophies.
Davide Basco +5 more
doaj +1 more source