Results 21 to 30 of about 21,278 (246)

Beneficial effects of propionyl L-carnitine therapy in diabetic cardiomyopathy [PDF]

Scripta Medica
In this review, the beneficial effects of metabolic therapy with propionyl L-carnitine (PPLC) on cardiovascular complications during the development of diabetic cardiomyopathy was evaluated.
Kaur Khushman, Kirshenbaum Lorrie, Tappia Paramjit S, Dhalla Naranjan S   +3 more
doaj   +1 more source

Skeletal Muscle Atrophy Induced by Diabetes Is Mediated by Non-Selective Channels and Prevented by Boldine

Biomolecules, 2023
Individuals with diabetes mellitus present a skeletal muscle myopathy characterized by atrophy. However, the mechanism underlying this muscular alteration remains elusive, which makes it difficult to design a rational treatment that could avoid the ...
Luis A. Cea, Walter Vásquez, Romina Hernández-Salinas, Alejandra Z. Vielma, Mario Castillo-Ruiz, Victoria Velarde, Magdiel Salgado, Juan C. Sáez   +7 more
doaj   +1 more source

Relaxing messages from the sarcolemma [PDF]

Journal of General Physiology, 2010
In spite of the detailed understanding reached in the last 50 years about the molecular mechanisms of muscle excitability, the localization of the Cl− conductance, GCl, in muscle has remained highly contended.
Zifarelli G, Pusch M
openaire   +4 more sources

Prestin amplifies cardiac motor functions

Cell Reports, 2021
Summary: Cardiac cells generate and amplify force in the context of cardiac load, yet the membranous sheath enclosing the muscle fibers—the sarcolemma—does not experience displacement.
Xiao-Dong Zhang, Phung N. Thai, Lu Ren, Maria Cristina Perez Flores, Hannah A. Ledford, Seojin Park, Jeong Han Lee, Choong-Ryoul Sihn, Che-Wei Chang, Wei Chun Chen, Valeriy Timofeyev, Jian Zuo, James W. Chan, Ebenezer N. Yamoah, Nipavan Chiamvimonvat   +14 more
doaj   +1 more source

Na⁺-K⁺-ATPase-G protein coupling in myocardial sarcolemma: separation and reconstitution [PDF]

, 1991
The cholinergic agonist carbachol produces a concentration-dependent (half-maximum inhibitory concentration = 0.9 μM) decrease in the Na+-K+-adenosine triphosphatase (ATPase) activity of rabbit cardiac sarcolemma that occurred only in the presence of ...
Vsevolod A. Tkachuk, Mikhail P. Danilenko, Oleg V. Yesirev, Vera C. Turmukhambetova, Mikhail P. Panchenko   +4 more
core   +3 more sources

Incorporation of Omega-3 Fatty Acids Into Human Skeletal Muscle Sarcolemmal and Mitochondrial Membranes Following 12 Weeks of Fish Oil Supplementation

Frontiers in Physiology, 2019
Fish oil (FO) supplementation in humans results in the incorporation of omega-3 fatty acids (FAs) eicosapentaenoic acid (EPA; C20:5) and docosahexaenoic acid (DHA; C20:6) into skeletal muscle membranes.
Christopher J. Gerling, Kazutaka Mukai, Adrian Chabowski, George J. F. Heigenhauser, Graham P. Holloway, Lawrence L. Spriet, Sebastian Jannas-Vela, Sebastian Jannas-Vela   +7 more
doaj   +1 more source

Hydrolysis of sarcolemma by lysosomal lipases and inhibition by chlorpromazine [PDF]

, 1982
The susceptibility of the lipids of canine cardiac sarcolemma to attack by soluble lysosomal lipases was studied to simulate in vitro the lipolytic injury that occurs during ischemia.
W. B. Weglicki, T. E. Knauer, K. Owens, J. K. Beckman   +3 more
core   +1 more source

Lysophosphatidylcholine induces arachidonic acid release and calcium overload in cardiac myoblastic H9c2 cells

Journal of Lipid Research, 1999
Lysophosphatidylcholine (lyso-PC) and arachidonate are products of phosphatidylcholine hydrolysis by phospholipase A2. In this study, the modulation of arachidonate release by exogenous lyso-PC in rat heart myoblastic H9c2 cells was examined.
Leonard S. Golfman, Norman J. Haughey, Jason T. Wong, Jenny Y. Jiang, Douglas Lee, Jonathan D. Geiger, Patrick C. Choy   +6 more
doaj   +1 more source

The effects of sucrose and arsenic on muscular insulin signaling pathways differ between the gastrocnemius and quadriceps muscles

Frontiers in Endocrinology, 2023
IntroductionInsulin resistance in muscle can originate from a sedentary lifestyle, hypercaloric diets, or exposure to endocrine-disrupting pollutants such as arsenic.
Pablo Pánico, Myrian Velasco, Ana María Salazar, Patricia Ostrosky-Wegman, Marcia Hiriart   +4 more
doaj   +1 more source

Caveolae regulation of mechanosensitive channel function in myotubes. [PDF]

PLoS ONE, 2013
Mutations that lead to muscular dystrophy often create deficiencies in cytoskeletal support of the muscle sarcolemma causing hyperactive mechanosensitive cation channel (MSC) activity and elevated intracellular Ca(2+).
Haixia Huang, Chilman Bae, Frederick Sachs, Thomas M Suchyna   +3 more
doaj   +1 more source