Results 71 to 80 of about 18,467 (180)

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

open access: yesPediatric Blood &Cancer, Volume 73, Issue 3, March 2026.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar   +8 more
wiley   +1 more source

Primary Ewing sarcoma of the kidney: a symptomatic presentation and review of the literature

open access: yesTherapeutic Advances in Urology, 2013
The objective of this review is to discuss the unique nature of primary renal Ewing sarcoma, including incidence, presentation and management. We also report on a common pattern of presentation, consisting of acute flank pain mimicking a renal stone ...
Tariq S. Hakky   +3 more
doaj   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

open access: yesPediatric Blood &Cancer, Volume 73, Issue 3, March 2026.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis   +13 more
wiley   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

open access: yesPediatric Blood &Cancer, Volume 73, Issue 3, March 2026.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack   +12 more
wiley   +1 more source

Impact of tissue staining and scanner variation on the performance of pathology foundation models: a study of sarcomas and their mimics

open access: yesThe Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Histopathological analysis is considered the gold standard for the diagnosis and prognostication of cancer. Recent advances in AI, driven by large‐scale digitisation and pan‐cancer foundation models, are opening new opportunities for clinical integration.
Binghao Chai   +74 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

open access: yesAdvanced Science, Volume 13, Issue 14, 9 March 2026.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang   +7 more
wiley   +1 more source

Integrative Genomic Profiling of Pediatric Solid Tumors Reveals Clinically Relevant Variants and Chromosomal Arm Aneuploidies Signatures

open access: yesCancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Pediatric malignancies have emerged as the leading cause of disease‐related mortality in children, exhibiting distinct etiological and molecular characteristics compared to adult cancers. Despite advances in genomic profiling, the molecular landscape of pediatric solid tumors, particularly in Chinese populations, remains ...
Bingxiao Yan   +22 more
wiley   +1 more source

Ewing's sarcoma [PDF]

open access: yesCancer, 1952
L J, McCORMACK   +2 more
openaire   +2 more sources

Pattern and Clinical Significance of CA19‐9 Expression in Human Cancer: A Tissue Microarray Study on 14,966 Tumors

open access: yesCancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Carbohydrate antigen 19–9 (CA19‐9) is a cell surface glycoprotein widely used as a diagnostic and prognostic serum marker for monitoring pancreatic cancer. The aim of this study was to evaluate the prevalence and clinical relevance of CA19‐9 expression in human cancer. Methods To comprehensively determine the prevalence and clinical
Nina Schraps   +31 more
wiley   +1 more source

Ewing Sarcoma of the Kidney, a Rare Entity: Case Report

open access: yesCase Reports in Medicine
Ewing sarcoma is a small round cell tumor of uncertain differentiation, primarily originating in bone in children and adolescents. Ewing sarcoma of the kidney is a rare occurrence and follows an aggressive course with early metastasis. Herein, we present
Alina Baral   +3 more
doaj   +1 more source

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