Results 81 to 90 of about 244,564 (198)

ESF-EMBO symposium "molecular biology and innovative therapies in sarcomas of childhood and adolescence" Sept 29–Oct 4, Polonia Castle Pultusk, Poland [PDF]

, 2013
Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic ...
Beat W. Schäfer, Simone eFulda, Heinrich eKovar, Heinrich Kovar, Beat W Schäfer, Koscielniak, Ewa, Ewa eKoscielniak, Fulda, Simone, Schäfer, Beat W, Kovar, Heinrich, Simone Fulda, Schäfer, Beat W., Ewa Koscielniak, Kovar H, Koscielniak E, Schäfer BW, Fulda S   +16 more
core   +1 more source

Vascular Control‐Focused Surgical Strategy for Pterygopalatine and Infratemporal Fossa Tumors Using Multimodal Image Fusion Reconstruction

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To classify tumor–internal maxillary artery (IMA) spatial relationships in pterygopalatine and infratemporal fossa (PPF/ITF) tumors, develop a 3D fusion–guided vascular control‐focused surgical strategy, and evaluate its clinical impact.
Zi‐Cheng He, Nian‐Zhen Zheng, Yong‐Quan Wang, Jia‐Rui Jiang, Chun‐Wei Li, Jian Li   +5 more
wiley   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-β-catenin pathway activation in Ewing sarcoma.

PLoS ONE
Ewing sarcoma is the second most common bone cancer in children, and while patients who present with metastatic disease at the time of diagnosis have a dismal prognosis.
Ryota Shirai, Tyler Biebighauser, Deandra Walker, Jillian Oviedo, Sarah Nelson-Taylor, Avery Bodlak, Timothy Porfilio, Naoki Oike, Andrew Goodspeed, Masanori Hayashi   +9 more
doaj   +1 more source

Targeting glutathione S-transferase M4 in Ewing sarcoma

Frontiers in Pediatrics, 2014
Ewing sarcoma is a malignant pediatric bone and soft tissue tumor. Although the 5-year survival rate of localized disease approaches 75%, the prognosis of metastatic and/or therapy-resistant disease remains dismal despite the wide use of aggressive ...
Rupeng eZhuo, kenneth ekosak, savita esankar, Elizabeth T Wiles, Ying eSun, Jianxing eZhang, Janet eAyello, Glenn ePrestwich, Paul eShami, Mitchell S Cairo, Stephen eLessnick, Wen eLuo   +11 more
doaj   +1 more source

Factors Affecting Surgical Outcomes Following Rotationplasty in Paediatric Sarcoma: A Literature Review

ANZ Journal of Surgery, EarlyView.
Rotationplasty is a durable limb‐salvage option for paediatric lower‐limb sarcoma. Across 58 studies and 1,217 patients, long‐term functional, psychosocial, and quality‐of‐life outcomes were favourable, often surpassing amputation and endoprosthetic reconstruction.
Rachel H. Ko, Stewart Morrison, Daniel J. Wilks   +2 more
wiley   +1 more source

SOX6: a double-edged sword for Ewing sarcoma

, 2020
Developmental pathways play an important role in cancer. We have recently demonstrated that the constitutive activation of the developmental transcription factor SOX6 via the fusion oncoprotein EWSR1-FLI1 (Ewing sarcoma breakpoint region 1 – Friend ...
Aruna Marchetto, Thomas G. P. Grünewald
core   +1 more source

Patient‐specific genomic measurable residual disease markers for monitoring acute myeloid leukaemia and myeloid malignancy

British Journal of Haematology, EarlyView.
Standardised DNA based measurable residual disease (MRD) monitoring is possible for acute myeloid leukaemia (AML) and myeloid malignancy patients. Targeted next‐generation sequencing (NGS) and RNA‐seq permit marker development for clinically identified lesions and whole genome sequencing (WGS) permits MRD marker development in patients without ...
Libby Huang, Louise Doculara, Luis Enriquez, Jodie Giles, Umma Habiba, Anita Y. Bahar, Tammy Law, Weronika Lesnowolska, Hannah McCalmont, Erika Ong, Laura Piras, Benjamin Schreiber, Nicola Venn, Wiebke Wessels, Yianni Bletas, Minjina Kang, Sam Yuen, Patrick Strong, Paulette Barahona, Ann‐Kristin Altekoester, Kimberly Dias, Dianne Sylvester, Marie Erasmus Wong, Renee Eslick, Luciano Dalla Pozza, Bhavna Padhye, Ashanka Beligaswatte, Chow Yee Lai, Michelle Ng, Chris Fraser, David Hughes, Seong Lin Khaw, Karen McCleary, Sophie Jessop, Manika Pal, Lucie Winkowska, Jan Zuna, Patrizia Larghero, Rolf Marschalek, Claus Meyer, Rishi S. Kotecha, Andrew S. Moore, Mark J. Cowley, Rosemary Sutton, Michelle J. Henderson, Toby N. Trahair   +45 more
wiley   +1 more source

Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing Sarcoma

Neoplasia: An International Journal for Oncology Research, 2019
Ewing sarcoma is a bone tumor most commonly diagnosed in adolescents and young adults. Survival for patients with recurrent or metastatic Ewing sarcoma is dismal and there is a dire need to better understand the mechanisms of cell metastasis specific to ...
Allegra G. Hawkins, Claire M. Julian, Sonja Konzen, Sydney Treichel, Elizabeth R. Lawlor, Kelly M. Bailey   +5 more
doaj   +1 more source

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

Brain Pathology, EarlyView.
Resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Chitra Sarkar, Maysa Al‐Hussaini, Vani Santosh, Vaishali Suri, Sung‐Hye Park, Yue‐Shan Piao, Tarik Tihan, Ho‐Keung Ng, Michael Buckland, Rakesh Jalali, Yonehiro Kanemura, Pieter Wesseling, Takashi Komori   +12 more
wiley   +1 more source