Results 131 to 140 of about 6,019,041 (305)

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Identification of new therapeutic targets for undifferentiated pleomorphic sarcoma

Undifferentiated pleomorphic sarcoma (UPS) is a rare and highly aggressive soft tissue sarcoma with vast unmet treatment needs, both in curative options and the prolongation of survival.
Danks, Molly Rebecca
core   +1 more source

Associations of Classic Kaposi Sarcoma with Common Variants in Genes that Modulate Host Immunity

, 2006
Classic Kaposi sarcoma (CKS) is an inflammatory-mediated neoplasm primarily caused by Kaposi sarcoma-associated herpesvirus (KSHV). Kaposi sarcoma lesions are characterized, in part, by the presence of proinflammatory cytokines and growth factors thought
WHITBY D, MBISA G, BROWN EE, SERRAINO D, FALLIN D, REZZA G, STAATS B, KAPOSI SARCOMA WORKING GROUP, LAURIA C, MESSINA A, HUTCHINSON A, RUCZINSKI I, CHANOCK SJ, VITALE, Francesco, GOEDERT JJ, TRAMUTO, Fabio   +15 more
core   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

A case series of necrotizing periodontal diseases in hospitalized patients: What hasn't been said yet?

Clinical Advances in Periodontics, EarlyView.
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal, Fernanda Bortolotto, Mariana Cristina Manoel, Gabriela Silveira de Araújo, Ana Carolina Fragoso Motta, Leandro Dorigan de Macedo, Lara Maria Alencar Ramos Innocentini, Joab Cabral Ramos, Isabel Schausltz Pereira Faustino   +8 more
wiley   +1 more source

Population-based Aarhus Sarcoma Registry: validity, completeness of registration, and incidence of bone and soft tissue sarcomas in western Denmark

Clinical Epidemiology, 2013
Katja Maretty-Nielsen,1,2 Ninna Aggerholm-Pedersen,1–3 Johnny Keller,1,4 Akmal Safwat,1,3 Steen Baerentzen,1,5 Alma B Pedersen6 1Sarcoma Centre of Aarhus University Hospital, 2Department of Experimental Clinical Oncology, 3Department of ...
Maretty-Nielsen K, Aggerholm-Pedersen N, Keller J, Safwat A, Baerentzen S, Pedersen AB   +5 more
doaj  

Preclinical models for the study of pediatric solid tumors: focus on bone sarcomas

Frontiers in Oncology
Sarcomas comprise between 10–15% of all pediatric malignancies. Osteosarcoma and Ewing sarcoma are the two most common pediatric bone tumors diagnosed in children and young adults.
D. Isabel Petrescu, Jason T. Yustein, Atreyi Dasgupta   +2 more
doaj   +1 more source

Delays in the management of retroperitoneal sarcomas. [Elektronisk resurs]

, 2010
Retroperitoneal sarcomas are rare and treatment should optimally be centralized. Despite successful centralization with 90% of the patients referred prior to surgery, delays occur, which led us to assess lead times in a population-based series.
Rydholm, Anders,, Almquist, Martin,, Seinen, Jojanneke, Lund University., Styring, Emelie,, Nilbert, Mef,   +5 more
core   +1 more source

Infrared Laser Heating Reveals a Reversible Phase Transition of Phosphofructokinase 1 in Mammalian Cells

Chemistry – A European Journal, EarlyView.
In this study, we present a novel method to investigate the phase behavior of biomolecular condensates in living cells. The method complements FRAP experiments, expanding the existing toolbox for characterization of condensates within living cells. ABSTRACT Metabolic enzymes can operate in concerted networks, so‐called metabolons.
Morten Mosbach, Sneha Pavanan Kuruvanthara, Lukas Johannknecht, Simon Ebbinghaus   +3 more
wiley   +1 more source

Multiple human herpesvirus-8 infection [PDF]

, 2003
In Malawian patients with Kaposi sarcoma (KS) and their relatives, we investigated nucleotide-sequence variation in human herpesvirus-8 (HHV-8) subgenomic DNA, amplified from oral and blood samples by use of polymerase chain reaction.
Teo, CG, Kondowe, W, Beyari, MM, Scully, CM, Cook, RD, Molyneux, EM, Porter, SR, Hodgson, TA   +7 more
core