Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group. [PDF]
, 2018 BackgroundNew prognostic markers are needed to identify patients with Ewing sarcoma (EWS) and osteosarcoma unlikely to benefit from standard therapy.
Barkauskas, Donald A +20 more
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Chemotherapy for soft tissue sarcoma
Cancer, 2016 Soft tissue sarcoma is a term used to describe a heterogeneous group of many rare tumors. Since the initial description of activity of doxorubicin, several additional agents have been brought to bear in the treatment of these diseases.
R. Ratan, Shreyaskumar R Patel
semanticscholar +1 more source
Don't cancel the surgery just yet! A case report of positive preoperative pregnancy test due to a soft tissue sarcoma production of ectopic beta human chorionic gonadotropin. [PDF]
, 2018 Soft tissue sarcomas are a rare group of mesenchymal malignancies which can range from low to high grade. These tumors have different clinical, radiographic, and histopathological characteristics. Beta human chorionic gonadotropin is a naturally secreted
Blank, Alan Todd +3 more
core
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine
Proceedings of the National Academy of Sciences of the United States of America, 1980 The protein kinase activity associated with pp60src, the transforming protein of Rous sarcoma virus, was found to phosphorylate tyrosine when assayed in an immunoprecipitate.
T. Hunter, B. Sefton
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Deciphering regulation in eukaryotic cell: from sequence to function [PDF]
arXiv, 2014 A transversal topic of my research has been the development and application of computational methods for DNA sequence analysis. The methods I have been developing aim at improving our understanding of the regulation processes happening in normal and cancer cells. This topic connects together the projects presented in this thesis.
arxiv
Phase Ib/II Study of the Safety and Efficacy of Combination Therapy with Multikinase VEGF Inhibitor Pazopanib and MEK Inhibitor Trametinib In Advanced Soft Tissue Sarcoma. [PDF]
, 2017 Purpose: Pazopanib, a multireceptor tyrosine kinase inhibitor targeting primarily VEGFRs1–3, is approved for advanced soft tissue sarcoma (STS) and renal cell cancer. Downstream of VEGFR, trametinib is an FDA-approved MEK inhibitor used for melanoma.
Azad, Nilofe A. +10 more
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Prognostic implications of PD-L1 expression in patients with soft tissue sarcoma
BMC Cancer, 2016 The PD-1/PD-L1 axis plays a paramount role in the immune escape of tumor cells by negative regulation of T-cell functions. The aim of the present study was to characterize the PD-L1 expression pattern and its clinical implication in soft-tissue sarcomas (
Chan Kim +17 more
semanticscholar +1 more source