Results 161 to 170 of about 340,819 (312)

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Coexistence of immunophenotypically normal and aberrant mast cells in patients with clonal mast cell diseases associates with more indolent subtypes and less severe disease characteristics

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Aberrant antigen expression on mast cells (MCs) is one of the most accurate diagnostic markers for clonal MC diseases (CMCD). Although the coexistence of normal and pathologic MCs is frequently seen, the disease characteristics associated with it have been minimally investigated.
Abdulrazzaq Alheraky, Kees Meijer, Marije Nijk, Saskia K. Klein, Hanneke N. G. Oude Elberink, Ido P. Kema, André B. Mulder   +6 more
wiley   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

Pediatric sarcomas: challenges and opportunities. [PDF]

Genes Dev
Gao Y, Bailey KM, Blackman SC, Bushweller JH, Chong S, DeHond K, Grembecka J, Hatley ME, Kadoch C, Koehler AN, Linardic CM, Renna P, Reu FJ, Rivera MN, Stewart EA, Stillman B, Sweet-Cordero EA, Stegmaier K, Vakoc CR, Guenther LM.   +19 more
europepmc   +1 more source

Primary Pulmonary Mesenchymal Neoplasm With EWSR1::CREM Fusion: Cytologic Findings and Molecular Diagnosis

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Primary pulmonary mesenchymal neoplasms with EWSR1::CREM fusion are rare. These lesions are challenging to diagnose by morphology and immunohistochemistry alone. Case A 66‐year‐old woman (ex‐smoker) was found to have a 1.3‐cm right lower lobe lung nodule that had grown very slowly over a 9‐year period.
Priya Upadhyay, Sanjay Mukhopadhyay, Swikrity U. Baskota   +2 more
wiley   +1 more source

Pseudokaposi′s sarcoma

Indian Dermatology Online Journal, 2014
Shylaja Someshwar, Hemangi R Jerajani
openaire   +3 more sources

Bone metastases in soft tissue sarcoma patients: a survey of natural history, prognostic value and treatment options

, 2013
Background: We surveyed the natural history of bone metastases in patients affected by soft tissue sarcoma (STS). Methods: This multicenter retrospective observational study included 135 patients.
Marianna Silletta, Marco Tucci, Giuseppe Tonini, Giacomo Giulio Baldi, Jeremy Simon Whelan, Anna Maria Frezza, Delia Delisi, Daniele Santini, Palma Dileo, Stefania Zovato, Rossana Berardi, Franco Silvestris, Angelo Paolo Dei Tos, Bruno Vincenzi, Roberto Tirabosco, Francesco Bertoldo, Giuseppe Badalamenti, Gaia Schiavon   +17 more
core  

Next-Generation Sequencing Refines Diagnosis and Expands Precision Medicine Opportunities in Soft Tissue Sarcomas. [PDF]

Int J Mol Sci
Tesser-Gamba F, Mendes TB, Lima FT, Abib SCV, Caran EMM, Toledo SRC.   +5 more
europepmc   +1 more source

Utility of Fine Needle Aspiration Supernatant for Real‐Time PCR–Based Mutation Analysis in Non–Small Cell Lung Cancer

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background The emergence of personalized therapy and molecular sequencing has significantly transformed the management of advanced non–small cell lung carcinoma (NSCLC). Supernatants obtained from fine needle aspiration (FNA) have been shown to be a reliable source of high‐quality nucleic acid for molecular testing.
Adeyinka Akinsanya, Riley Gorden, Madison Rector, Hamna Muhammad, Melissa Randolph, Matt Sperling, Kemin Xu, Sheila Segura, Omer Saeed, Tieying Hou   +9 more
wiley   +1 more source

Prognostic Significance of the Ki-67 Index with an Optimal Cut-off Value of 32.5% in Uterine Sarcoma and Uterine Carcinosarcoma: A Retrospective Cohort Study. [PDF]

Int J Womens Health
Ye P, Wang F, Dai X, Hu X, Wang Y.
europepmc   +1 more source