Results 51 to 60 of about 734,103 (389)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Myoepithelial carcinoma of the paracecal mesentery: aggressive behavior of a rare neoplasm at an unusual anatomic site

Rare Tumors, 2017
Myoepithelial tumors of the soft tissues represent a rare group of neoplasms that vary in their clinical behavior, pathologic features and genetics. They are histopathologically typified by a myoepithelial immunohistochemical phenotype, of expression of ...
Khin Thway, Jonathan Noujaim, D. Michael Thomas, Cyril Fisher, Robin L. Jones   +4 more
doaj   +1 more source

BMN673 sensitizes rhabdomyosarcoma tumors to irradiation in vivo [PDF]

, 2020
Bone and soft tissue sarcomas are mesenchymal tumors that occur rarely in adults, representing only 1% of total malignancies, but comprise up to 13% of malignant tumors in children.1 Rhabdomyosarcoma, a soft tissue sarcoma that commonly affects children,
Jacob, Connor
core  

Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model. [PDF]

, 2016
A patient with high grade undifferentiated pleomorphic soft-tissue sarcoma from a striated muscle was grown orthotopically in the right biceps femoris muscle of mice to establish a patient-derived orthotopic xenograft (PDOX) model.
Bouvet, Michael, Chawla, Sant, Chishima, Takashi, DeLong, Jonathan, Deng, Samantha, Eilber, Fritz C, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Matsuyama, Ryusei, Murakami, Takashi, Quan, Cuong, Reynoso, Jose, Russell, Tara, Singh, Arun, Tanaka, Kuniya, Zhang, Nan, Zhang, Yong, Zhao, Ming   +18 more
core   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

New strategies in soft tissue sarcoma treatment

Journal of Hematology & Oncology
Soft tissue sarcomas (STS) have long been a formidable challenge in oncology, partly because of their rarity and diversity, which complicates large-scale studies and slows the advent of new treatments.
Mariella Spalato-Ceruso, Nathan El Ghazzi, Antoine Italiano   +2 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Setting the international research agenda for sarcomas with patients and carers: results of phase II of the Sarcoma Patient Advocacy Global Network (SPAGN) priority setting partnership

BMC Cancer
Background Typically, researchers and clinicians determine the agenda in sarcoma research. However, patient involvement can have a meaningful impact on research.
E. Roets, K. Schuster, S. Bickley, M. Wartenberg, O. Gonzato, N. Fernandez, B. Kasper, K. Pilgermann, R. Wilson, N. Steeghs, W. T. A. van der Graaf, G. van Oortmerssen, O. Husson   +12 more
doaj   +1 more source

The effect of helper virus on Abelson virus-induced transformation of lymphoid cells [PDF]

, 1978
Abelson murine leukemia virus (A-MuLV)-transformed fibroblast nonproducer cells were used to prepare A-MuLV stocks containing a number of different helper viruses.
Baltimore, David, Rosenberg, Naomi
core   +2 more sources

An update on the management of sporadic desmoid-type fibromatosis: a European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG)

Annals of Oncology, 2017
Desmoid-type fibromatosis is a rare and locally aggressive monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course.
B. Kasper, C. Baumgarten, J. García, S. Bonvalot, R. Haas, F. Haller, P. Hohenberger, N. Penel, C. Messiou, W. V. D. van der Graaf, A. Gronchi, S J Y F P H R M V R I C K A L H J P S E C K E M Bauer Blay van Coevorden Dileo Dürr Fiore Grünwald, S. Bauer, J. Blay, F. van Coevorden, P. Dileo, H. Dürr, M. Fiore, V. Grünwald, R. Jones, I. Judson, C. Kettelhack, K. Kopeckova, A. Lazar, L. Lindner, J. Martín-Broto, P. Rutkowski, S. Stacchiotti, E. Stoeckle, C. Valverde, K. Verhoef, E. Wardelmann, M. Wartenberg   +32 more
semanticscholar   +1 more source